Brief Title
The Effects of Anesthesia on Patients Undergoing Surgery for Repair of a Thoracoabdominal Aneurysm.
Official Title
The Effect of Anesthesia on Potential Cerebrospinal Fluid (CSF) and Serum Markers of Alzheimer's Disease.
Brief Summary
Alzheimer's disease represents a growing public health problem in developed countries. Although the pathogenesis is not clearly defined, accumulation of extracellular amyloid, neurofibrillary tangles and neuronal loss are the hallmarks of Alzheimer's disease. The effect of anesthetic agents on changes in these proteins in humans is not well characterized, but in-vitro evidence suggests that anesthetic agents can accelerate potential pathogenic mechanisms, such as increasing amyloid formation or rates of apoptosis in cultured cells and increasing amyloid levels in mice. Human data on the effect of anesthetic agents on amyloid and tau proteins is limited to a small series of 11 patients and showed a significant increase in tau levels after exposure to anesthetics. In this study the investigators propose to measure CSF and serum biomarkers in a population of patients with normal CSF dynamics, who are undergoing surgery for repair of a thoracoabdominal aneurysm. The investigators will also obtain preliminary data on whether changes in CSF levels of these proteins are associated with postoperative delirium or cognitive change.
Study Type
Interventional
Primary Outcome
Changes in Cerebrospinal Fluid (CSF) Levels of Tau
Secondary Outcome
Number of Participants With Delirium as Assessed by the Confusion Assessment Method (CAM)
Condition
Thoracic Aneurysm
Intervention
Propofol
Study Arms / Comparison Groups
Open repair of thoracoabdominal aneurysms
Description: These will be patients undergoing an open repair of thoracoabdominal aneurysms with or without cardiopulmonary bypass. The will be observational only.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Drug
Estimated Enrollment
14
Start Date
May 2012
Completion Date
February 2014
Primary Completion Date
February 2014
Eligibility Criteria
Inclusion Criteria: - age 21-100 years of age - Patients presenting for surgical repair of a thoracoabdominal aneurysm - Insertion of a CSF spinal drain for clinically indicated reason Exclusion Criteria: - Patients with pre-existing delirium - Inability to speak and understand English - Severe hearing impairment, resulting in inability to converse - Pregnancy. Pregnancy status will be assessed using a serum pregnancy test during preoperative evaluation as part of the standard of care.
Gender
All
Ages
21 Years - 100 Years
Accepts Healthy Volunteers
No
Contacts
Charles Brown, MD, ,
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT01772537
Organization ID
NA_00067716
Secondary IDs
5KL2RR025006
Responsible Party
Sponsor
Study Sponsor
Johns Hopkins University
Collaborators
National Center for Research Resources (NCRR)
Study Sponsor
Charles Brown, MD, Principal Investigator, Johns Hopkins University
Verification Date
March 2017