Impact of Limb Remote Ischemic Preconditioning on Mortality and Quality of Life During Abdominal Aortic Aneurysm Repair

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Abdominal aortic aneurysm
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Brief Title

Impact of Limb Remote Ischemic Preconditioning on Mortality and Quality of Life During Abdominal Aortic Aneurysm Repair

Official Title

Impact of Limb Remote Ischemic Preconditioning on Mortality, Hospitalization Costs and Quality of Life During Elective Abdominal Aortic Aneurysm Repair: a Randomized Controlled Trial

Brief Summary

      To investigate the influence of limb remote ischemic preconditioning (LRIP) on mortality,
      hospitalization costs and quality of life in patients undergoing open infrarenal abdominal
      aortic aneurysm (AAA) repair.

Detailed Description

      Remote ischaemic preconditioning may confer the cytoprotection in critical organs. The
      investigators have revealed that limb remote ischemic preconditioning (RIPC) would reduce
      intestinal and pulmonary injury in patients undergoing open infrarenal abdominal aortic
      aneurysm (AAA) repair.Few groups have investigated the long term influence of limb remote
      ischemic preconditioning.Therefore, the investigators evaluated the impact of limb remote
      ischemic preconditioning on mortality, hospitalization costs and quality of life during
      elective abdominal aortic aneurysm repair in a prospective, randomized, controlled, single
      blind setting.

Study Type

Interventional

Primary Outcome

all cause mortality

Secondary Outcome

 hospitalization costs

Condition

Abdominal Aortic Aneurysm

Intervention

limb RIPC

Study Arms / Comparison Groups

 limb RIPC
Description:  limb RIPC protocol was applied after anesthetic induction and before the start of surgery. The limb RIPC was induced by placing a blood pressure cuff on the left upper arm of patient for three inflating-deflating cycles: 5 min inflating to 200 mmHg followed by a 5 min reperfusion with deflating the cuff.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Procedure

Estimated Enrollment

360

Start Date

August 2013

Completion Date

September 2015

Primary Completion Date

August 2015

Eligibility Criteria

        Inclusion Criteria:

          -  Clinical diagnosis of abdominal aortic aneurysm

          -  Must be received open abdominal aortic aneurysm repair

        Exclusion Criteria:

          -  age >80 years old

          -  Acute coronary syndrome or myocardial infraction within 3 months

          -  Chronic obstructive pulmonary emphysema

          -  angina pain within 48 hours of repair procedure

          -  ejection fraction less than 40%

          -  poor pulmonary function (PaO2 <60mmHg)

Gender

All

Ages

18 Years - 80 Years

Accepts Healthy Volunteers

No

Contacts

Kexuan Liu, PhD, +86-18602017796, [email protected]

Administrative Informations

NCT ID

NCT01910961

Organization ID

LRIP

Secondary IDs

Liu Kexuan

Responsible Party

Sponsor-Investigator

Study Sponsor

Cai Li

Collaborators

 Huazhong University of Science and Technology

Study Sponsor

Kexuan Liu, PhD, Principal Investigator, First Affiliated Hospital, Sun Yat-Sen University

Verification Date

July 2013