Brief Title
Impact of Limb Remote Ischemic Preconditioning on Mortality and Quality of Life During Abdominal Aortic Aneurysm Repair
Official Title
Impact of Limb Remote Ischemic Preconditioning on Mortality, Hospitalization Costs and Quality of Life During Elective Abdominal Aortic Aneurysm Repair: a Randomized Controlled Trial
Brief Summary
To investigate the influence of limb remote ischemic preconditioning (LRIP) on mortality, hospitalization costs and quality of life in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair.
Detailed Description
Remote ischaemic preconditioning may confer the cytoprotection in critical organs. The investigators have revealed that limb remote ischemic preconditioning (RIPC) would reduce intestinal and pulmonary injury in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair.Few groups have investigated the long term influence of limb remote ischemic preconditioning.Therefore, the investigators evaluated the impact of limb remote ischemic preconditioning on mortality, hospitalization costs and quality of life during elective abdominal aortic aneurysm repair in a prospective, randomized, controlled, single blind setting.
Study Type
Interventional
Primary Outcome
all cause mortality
Secondary Outcome
hospitalization costs
Condition
Abdominal Aortic Aneurysm
Intervention
limb RIPC
Study Arms / Comparison Groups
limb RIPC
Description: limb RIPC protocol was applied after anesthetic induction and before the start of surgery. The limb RIPC was induced by placing a blood pressure cuff on the left upper arm of patient for three inflating-deflating cycles: 5 min inflating to 200 mmHg followed by a 5 min reperfusion with deflating the cuff.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Procedure
Estimated Enrollment
360
Start Date
August 2013
Completion Date
September 2015
Primary Completion Date
August 2015
Eligibility Criteria
Inclusion Criteria: - Clinical diagnosis of abdominal aortic aneurysm - Must be received open abdominal aortic aneurysm repair Exclusion Criteria: - age >80 years old - Acute coronary syndrome or myocardial infraction within 3 months - Chronic obstructive pulmonary emphysema - angina pain within 48 hours of repair procedure - ejection fraction less than 40% - poor pulmonary function (PaO2 <60mmHg)
Gender
All
Ages
18 Years - 80 Years
Accepts Healthy Volunteers
No
Contacts
Kexuan Liu, PhD, +86-18602017796, [email protected]
Administrative Informations
NCT ID
NCT01910961
Organization ID
LRIP
Secondary IDs
Liu Kexuan
Responsible Party
Sponsor-Investigator
Study Sponsor
Cai Li
Collaborators
Huazhong University of Science and Technology
Study Sponsor
Kexuan Liu, PhD, Principal Investigator, First Affiliated Hospital, Sun Yat-Sen University
Verification Date
July 2013