Brief Title
Risk Factors in the Initial Presentation of Specific Cardiovascular Disease Syndromes
Official Title
Cardiovascular Risk Factors in the Initial Presentation of Specific Cardiovascular Disease Syndromes: a CALIBER Proposal Using Linked GPRD-MINAP-HES Data
Brief Summary
Cardiovascular disease (CVD) is an important public health problem that affects millions of
people worldwide. Associations between risk factors, such as smoking, dyslipidaemia or
hypertension, and prevalent CVD are well documented. However, few studies have investigated
associations with onset of disease. The initial manifestation of CVD, for example an episode
of unstable angina, is important because it influences the prognosis, the quality of life and
the management of disease. Furthermore, the extent to which social deprivation, alcohol
consumption or atrial fibrillation affects presentation of CVD is poorly understood and
deserves further consideration.
Most previous studies have considered CVD as a single entity. However, differences in
aetiology between coronary phenotypes suggest that risk factors may not be shared across
specific coronary phenotypes and their relative importance is likely to differ for each
phenotype. Gaining knowledge of these differences could provide insights into the
pathophysiology of specific forms of CVD and could eventually lead to modification of
recommendations for patient management and disease prevention.
We propose to use the linkage of the national registry of coronary events to general practice
records in the Clinical Practice Research Database (CPRD), to investigate whether
demographic, behavioral, and clinico-metabolic risk factors differentially influence the
onset of specific types of CVD.
Study Type
Observational [Patient Registry]
Primary Outcome
First presentation of cardiovascular disease, as specified in description
Secondary Outcome
Non CVD specific deaths
Condition
Heart Diseases
Study Arms / Comparison Groups
CALIBER Healthy Cohort
Description: We will report findings from the CALIBER (CArdiovascular disease research using Linked BEspoke studies and Electronic Records) collaboration where we linked primary care data (from the General Practice Research Database [GPRD]) to three further sources of electronic health records: the Myocardial Ischemia National Audit Project registry (MINAP),cause specific discharge data from Hospital Episodes Statistics (HES) and cause specific mortality from the Office for National Statistics (ONS).
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
2240000
Start Date
January 1997
Completion Date
March 2010
Primary Completion Date
March 2010
Eligibility Criteria
Inclusion Criteria:
- Aged ≥30yrs old
- Registered in CPRD practices in England consenting to data linkage
- ≥1 year of up-to-standard pre-study follow-up
Exclusion Criteria:
- History of any of the CVD endpoints considered before study follow-up initiation.
Gender
All
Ages
30 Years - N/A
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
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Administrative Informations
NCT ID
NCT01804439
Organization ID
CALIBER 12_153R
Responsible Party
Principal Investigator
Study Sponsor
University College, London
Study Sponsor
, ,
Verification Date
March 2013