Brief Title
Mechanism and Prevention of Remote Organ Injury Following Ruptured Aortic Aneurysm
Official Title
Phase 1 Study of Complement Activation Following Ruptured Abdominal Aortic Aneurysm: Combining Human Observation With Animal Experimentation to Establish a Framework for Human Therapy
Brief Summary
It has been estimated that 80% of deaths from abdominal aortic aneurysms results from rupture. Endovascular Aneurysm Repair (EVAR) has been applied to RAAA (Ruptured Abdominal Aortic Aneurysm) patients with reports of improvements. Despite the use of EVAR, patients have developed complications with lung and kidney function. This study will investigate certain biochemical processes that will potentially reduce these complications. Knowledge gained from this study may also be used to further research in this field through larger studies.
Study Type
Observational
Primary Outcome
Mortality
Secondary Outcome
multiple organ failure
Condition
Abdominal Aortic Aneurysm
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
24
Start Date
January 2006
Completion Date
December 2010
Primary Completion Date
June 2010
Eligibility Criteria
Inclusion Criteria: - Open/Elective EVAR patients Exclusion Criteria: - Patients who do not present with abdominal aortic aneurysms or ruptured abdominal aortic aneurysm
Gender
All
Ages
30 Years - 80 Years
Accepts Healthy Volunteers
No
Contacts
Thomas F Lindsay, MD, ,
Location Countries
Canada
Location Countries
Canada
Administrative Informations
NCT ID
NCT00416000
Organization ID
06-0671B
Responsible Party
Principal Investigator
Study Sponsor
University Health Network, Toronto
Collaborators
The Physicians' Services Incorporated Foundation
Study Sponsor
Thomas F Lindsay, MD, Principal Investigator, TGH, UHN
Verification Date
May 2014