Brief Title
Reduction of Myocardial Infarction by Preconditioning in Patients With Ruptured Abdominal Aortic Aneurysm
Official Title
Reduction of Myocardial Infarction by Preconditioning in Patients With Ruptured Abdominal Aortic Aneurysm
Brief Summary
Preconditioning in patients treated for elective abdominal aneurysm showed that the rate of perioperative myocardial infarction could be reduced by 80 %(ARR from 27% to 5%). Precondition where performed by 10 minutes of clamping of each iliac arteries before clamping the abdominal aorta. Human studies in cardiac patients have shown promising results with precondition. Instead of clamping arteries they have all performed the procedure by inflating a blood pressure cuff above arterial pressure on a arm. The investigators want to investigate if preconditioning induced by a blood pressure cuff on a arm can reduce the perioperative rate of myocardial infarction in patients open operated for ruptured abdominal aortic aneurysm.
Study Type
Interventional
Primary Outcome
Reduction in myocardial infarction
Secondary Outcome
Improvement in survival Description on inflammatory response
Condition
Abdominal Aortic Aneurysm
Intervention
Precondition
Study Arms / Comparison Groups
Precondition
Description: Induction of precondition at start of operation on a arm
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Procedure
Estimated Enrollment
200
Start Date
April 2009
Completion Date
December 2014
Primary Completion Date
December 2014
Eligibility Criteria
Inclusion Criteria: - Patients with ruptured abdominal aortic aneurysm offered surgery - Age > 18 years Exclusion Criteria: - Technical inoperable
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
Nikolaj Eldrup, MD PhD, ,
Location Countries
Denmark
Location Countries
Denmark
Administrative Informations
NCT ID
NCT00883363
Organization ID
NE_RAAA_PRECON_01
Responsible Party
Sponsor-Investigator
Study Sponsor
Nikolaj Eldrup
Collaborators
Aarhus University Hospital
Study Sponsor
Nikolaj Eldrup, MD PhD, Principal Investigator, Aarhus University Hospital Skejby
Verification Date
January 2015