Reduction of Myocardial Infarction by Preconditioning in Patients With Ruptured Abdominal Aortic Aneurysm

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Abdominal aortic aneurysm
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Cook – Abdominal aortic aneurysm Cordis Corporation – Abdominal Aortic Aneurysm
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Brief Title

Reduction of Myocardial Infarction by Preconditioning in Patients With Ruptured Abdominal Aortic Aneurysm

Official Title

Reduction of Myocardial Infarction by Preconditioning in Patients With Ruptured Abdominal Aortic Aneurysm

Brief Summary

      Preconditioning in patients treated for elective abdominal aneurysm showed that the rate of
      perioperative myocardial infarction could be reduced by 80 %(ARR from 27% to 5%).
      Precondition where performed by 10 minutes of clamping of each iliac arteries before clamping
      the abdominal aorta. Human studies in cardiac patients have shown promising results with
      precondition. Instead of clamping arteries they have all performed the procedure by inflating
      a blood pressure cuff above arterial pressure on a arm.

      The investigators want to investigate if preconditioning induced by a blood pressure cuff on
      a arm can reduce the perioperative rate of myocardial infarction in patients open operated
      for ruptured abdominal aortic aneurysm.

Study Type

Interventional

Primary Outcome

Reduction in myocardial infarction

Secondary Outcome

 Improvement in survival Description on inflammatory response

Condition

Abdominal Aortic Aneurysm

Intervention

Precondition

Study Arms / Comparison Groups

 Precondition
Description:  Induction of precondition at start of operation on a arm

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Procedure

Estimated Enrollment

200

Start Date

April 2009

Completion Date

December 2014

Primary Completion Date

December 2014

Eligibility Criteria

        Inclusion Criteria:

          -  Patients with ruptured abdominal aortic aneurysm offered surgery

          -  Age > 18 years

        Exclusion Criteria:

          -  Technical inoperable

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

Nikolaj Eldrup, MD PhD, ,

Location Countries

Denmark

Location Countries

Denmark

Administrative Informations

NCT ID

NCT00883363

Organization ID

NE_RAAA_PRECON_01

Responsible Party

Sponsor-Investigator

Study Sponsor

Nikolaj Eldrup

Collaborators

 Aarhus University Hospital

Study Sponsor

Nikolaj Eldrup, MD PhD, Principal Investigator, Aarhus University Hospital Skejby

Verification Date

January 2015