Brief Title
Limb Remote Ischemic Preconditioning Reduces Heart and Lung Injury After Abdominal Aortic Aneurysm Repair
Official Title
Limb Remote Ischemic Preconditioning Reduces Heart and Lung Injury After Abdominal Aortic Aneurysm Repair:A Randomized Controlled Trial
Brief Summary
To investigate whether limb remote ischemic preconditioning (LRIP) has protective effects against intestinal and pulmonary injury in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair.
Detailed Description
Remote ischaemic preconditioning may confer the cytoprotection in critical organs. We hypothesized that limb remote ischemic preconditioning (RIPC) would reduce intestinal and pulmonary injury in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair.The primary outcomes included the biomarkers reflecting intestinal injury (serum intestinal fatty acid binding protein, endotoxin levels and diamine oxidase activity) and the variables reflecting pulmonary injury (arterial-alveolar oxygen tension ratio, alveolar-arterial oxygen tension difference and respiratory index). In addition, the severity of intestinal and pulmonary injury was assessed with different scoring methods, respectively. Markers of oxidative stress and systemic inflammation were measured as well.
Study Type
Interventional
Primary Outcome
Limb remote ischemic preconditioning has effective protection of lung injury in patients undergoing elective open abdominal aortic aneurysm repair
Condition
Abdominal Aortic Aneurysm
Intervention
Limb remote ischemic preconditioning(LRIP)
Study Arms / Comparison Groups
Limb RIPC
Description: The limb RIPC protocol was applied after anesthetic induction and before the start of surgery. The limb RIPC was induced by placing a blood pressure cuff on the left upper arm of patient for three inflating-deflating cycles: 5 min inflating to 200 mmHg followed by a 5 min reperfusion with deflating the cuff.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Procedure
Estimated Enrollment
62
Start Date
January 2008
Completion Date
June 2011
Primary Completion Date
May 2011
Eligibility Criteria
Inclusion Criteria: - Clinical diagnosis of abdominal aortic aneurysm - Must be received open abdominal aortic aneurysm repair Exclusion Criteria: - age >80 years old - Acute coronary syndrome or myocardial infraction within - 3 months - Chronic obstructive pulmonary emphysema - angina pain within 48 hours of repair procedure - ejection fraction less than 40% - poor pulmonary function (PaO2 <60mmHg) - history of inflammatory bowel disease - history of diarrhea (≥2 liquid stools per day for ≥2 days) within 1 week of surgery - intestinal chronic inflammatory disease
Gender
All
Ages
20 Years - 80 Years
Accepts Healthy Volunteers
No
Contacts
Ke-Xuan Liu, Ph.D, ,
Administrative Informations
NCT ID
NCT01344239
Organization ID
LRIP701126
Secondary IDs
CLi
Responsible Party
Sponsor-Investigator
Study Sponsor
Cai Li
Study Sponsor
Ke-Xuan Liu, Ph.D, Principal Investigator, First Affiliated Hospital, Sun Yat-Sen University
Verification Date
May 2013