Limb Remote Ischemic Preconditioning Reduces Heart and Lung Injury After Abdominal Aortic Aneurysm Repair
Limb Remote Ischemic Preconditioning Reduces Heart and Lung Injury After Abdominal Aortic Aneurysm Repair:A Randomized Controlled Trial
To investigate whether limb remote ischemic preconditioning (LRIP) has protective effects against intestinal and pulmonary injury in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair.
Remote ischaemic preconditioning may confer the cytoprotection in critical organs. We hypothesized that limb remote ischemic preconditioning (RIPC) would reduce intestinal and pulmonary injury in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair.The primary outcomes included the biomarkers reflecting intestinal injury (serum intestinal fatty acid binding protein, endotoxin levels and diamine oxidase activity) and the variables reflecting pulmonary injury (arterial-alveolar oxygen tension ratio, alveolar-arterial oxygen tension difference and respiratory index). In addition, the severity of intestinal and pulmonary injury was assessed with different scoring methods, respectively. Markers of oxidative stress and systemic inflammation were measured as well.
Limb remote ischemic preconditioning has effective protection of lung injury in patients undergoing elective open abdominal aortic aneurysm repair
Abdominal Aortic Aneurysm
Limb remote ischemic preconditioning(LRIP)
Study Arms / Comparison Groups
Description: The limb RIPC protocol was applied after anesthetic induction and before the start of surgery. The limb RIPC was induced by placing a blood pressure cuff on the left upper arm of patient for three inflating-deflating cycles: 5 min inflating to 200 mmHg followed by a 5 min reperfusion with deflating the cuff.
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Primary Completion Date
Inclusion Criteria: - Clinical diagnosis of abdominal aortic aneurysm - Must be received open abdominal aortic aneurysm repair Exclusion Criteria: - age >80 years old - Acute coronary syndrome or myocardial infraction within - 3 months - Chronic obstructive pulmonary emphysema - angina pain within 48 hours of repair procedure - ejection fraction less than 40% - poor pulmonary function (PaO2 <60mmHg) - history of inflammatory bowel disease - history of diarrhea (≥2 liquid stools per day for ≥2 days) within 1 week of surgery - intestinal chronic inflammatory disease
20 Years - 80 Years
Accepts Healthy Volunteers
Ke-Xuan Liu, Ph.D, ,
Ke-Xuan Liu, Ph.D, Principal Investigator, First Affiliated Hospital, Sun Yat-Sen University