Brief Title
Study on Anti-inflammatory Effect of Anti-hypertensive Treatment in Patients With Small AAA's and Mild Hypertension
Official Title
An Open-label PET-observer-blinded Pilot Study of the Effect of Aliskiren- Versus Amlodipine-based Antihypertensive Treatment in Patients With Small Abdominal Aortic Aneurysm and Mild to Moderate Hypertension on Aneurysmal FDG-uptake
Brief Summary
Inflammation of the blood vessel plays an important role in the development and growth of a
dilated abdominal aorta. An elevated blood pressure leads to an increase in inflammation,
therefore blood pressure lowering is an important part of the treatment of patients with a
dilated abdominal aorta who also have an elevated blood pressure. In the investigators study
the investigators compare the anti-inflammatory effects of 2 different blood pressure
lowering strategies. The investigators hypothesize that both strategies will decrease
inflammation, however the investigators believe the total decrease of inflammation depends on
the type of blood pressure lowering medication used.
Detailed Description
Standard therapy of small AAAs currently consists of "watchful waiting" strategy with
aggressive blood pressure control "Watchful waiting" includes an Ultrasound (more recently CT
or MRI scan) every 12 months (for AAAs between 3.5 - 4.4 cm) or every 6 months (for AAAs
between 4.5 and 5.5 cm) to observe. A growth rate of >7 mm/ 6 months has been suggested as a
threshold for proceeding to aneurysm repair irrespective of aneurysm size. Clearly, there is
need for a more sensitive method to evaluate the progress of AAA growth.
Recent publications have shown that evaluation of AAAs using FDG-uptake with PET-scan may
identify small AAAs that are more prone to grow and/or rupture, as these AAAs as compared to
normal aorta's show increased inflammatory activity , which is considered the major
pathophysiological pathway. Evaluation of FDG-uptake is also sensitive enough to observe the
short-term effects of endovascular intervention of large AAAs, as unpublished data show a
statistically significant reduction in aneurismal FDG-uptake only 6 weeks after endovascular
repair of large AAAs. Therefore, the change in aneurismal FDG-uptake may also be a very
promising and sensitive method to evaluate treatment effects of medical interventions within
a relatively short period of time (3 months).
Just as pressure unloading may represent an anti-inflammatory mechanism in endovascular
repair of more advanced aneurysms, so may milder pressure unloading in moderately
hypertensive individuals with smaller aneurysms display similar anti-inflammatory effects.
Such a mild form of pressure unloading may be attainable with adequate anti-hypertensive drug
therapy. In this context, however, a possible additional benefit may be that some
anti-hypertensive drug classes have been proposed to exert specific anti-inflammatory effects
relevant to aneurysm inflammation.
Local activation of multiple components of the renin angiotensin system has been implicated
in both the development of aneurysms, as well as in their inflammatory component. In
accordance, preliminary evidence from murine studies suggest that ACE inhibitors, for
example, may reduce inflammatory activity in aneurysmatic vessel walls. However, since ACE
inhibitors block the renin angiotensin system halfway it's path, and non-ACE conversion of
angiotensin I occurs, a rationale exists to block the renin angiotensin system upstream of
ACE. Upstream blockade of the renin-angiotensin system may have additional advantages in
antagonising direct pro-inflammatory effects of renin itself, which have been identified in,
for example, kidney tissue and retinal microvessels.
A case can thus be made for renin inhibition as a potential optimal strategy for reducing
aneurysm inflammation in hypertensive patients with aortic aneurysms. In the proposed pilot
trial, the direct renin inhibitor Aliskiren will be evaluated. As a control condition, an
antihypertensive agent without postulated specific anti-inflammatory effects is appropriate.
Calcium channel blockers represent such a class.
The current study will explore what the size and variability of the effect of aliskiren
monotherapy, the combination of aliskiren/hydrochlorothiazide, amlodipine monotherapy, or the
combination of amlodipine/hydrochlorothiazide on FDG-uptake is (if at all measurable on top
of the effect of antihypertensive and statin therapy). This will allow more accurate power
calculation of larger future studies aiming at prevention of AAA-progression (diameter and
rupture).
Study Type
Interventional
Primary Outcome
Change in aneurysmal vessel wall inflammation
Secondary Outcome
Change in abdominal aortic aneurysm diameter
Condition
Hypertension
Intervention
Aliskiren
Study Arms / Comparison Groups
Aliskiren
Description: Half of all subjects with mild to moderate hypertension and a small abdominal aortic aneurysm are treated with aliskiren, combined with hydrochlorothiazide if hypertension cannot be treated sufficiently with aliskiren monotherapy
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Drug
Estimated Enrollment
3
Start Date
September 2011
Completion Date
December 2013
Primary Completion Date
December 2013
Eligibility Criteria
Inclusion Criteria:
1. Patients with a proven AAA of >30 mm and < 55 mm
2. Age between 18 and 75y (both inclusive)
3. Weight > 50 kg
4. Mild to moderate hypertension (defined as 130 < msSBP < 180 or 85< msDBP <110), at
screening and/or baseline, without current antihypertensive medication.
Exclusion Criteria:
1. Patients without an AAA, or with an AAA ≥ 55 mm, or ≤ 30 mm
2. Patients with an AAA who are eligible for surgical repair for any reason
3. Diabetes mellitus
4. Inability of the subjects to switch from all prior antihypertensive medications safely
as required by the protocol and need for drugs other than study drugs at the time of
baseline
5. Severe hypertension (msSBP ≥180 mmHg and/or msDBP ≥110 mmHg) at screening and/or
baseline
6. Pregnant or nursing (lactating) women
7. Known or suspected contraindications, including history of allergy or hypersensitivity
(such as angioedema) to DRIs, CCBs, ACEIs, statins, acetylsalicylic acid or diuretics
in general (for example, to aliskiren / amlodipine / hydrochlorothiazide / statins)
8. Concomitant drugs that are strong inhibitors of CYP3A4 or P-glycoprotein inhibitors
(ketoconazole, itraconazole, nefazodone, clarithromycin, ritonavir, nelfinavir,
cyclosporine, verapamil, quinidine)
9. Previous or current diagnosis of heart failure (NYHA Class II-IV)
10. Second or third degree heart block without a pacemaker, or potentially
life-threatening arrhythmia during the 12 months prior to screening
11. Clinically symptomatic valvular heart disease at screening visit
12. A past medical history of clinically significant ECG abnormalities
13. Confirmed serum potassium ≥5.3 mEq/L (mmol/L) at screening or baseline.
14. Impaired renal function, defined as eGFR < 45 mL/min/1.73 m2 MDRD
15. Donation or loss of 400 ml or more of blood within eight (8) weeks prior to initial
dosing, or longer if required by local regulation
16. Participation in any clinical investigation within four (4) weeks prior to first dose
or longer if required by local regulations, and for any other limitation of
participation based on local regulations.
17. Patients who have undergone prior radionuclide treatment or examinations or X-ray
examinations with a cumulative radiation exposure, which added to the radiation
exposure of the current study, would exceed local limits.
Gender
All
Ages
18 Years - 75 Years
Accepts Healthy Volunteers
No
Contacts
Jan D Blankensteijn, MD, PhD, ,
Location Countries
Netherlands
Location Countries
Netherlands
Administrative Informations
NCT ID
NCT01425242
Organization ID
AAA-PET/CT vumc
Secondary IDs
2011-000538-12
Responsible Party
Principal Investigator
Study Sponsor
Amsterdam UMC, location VUmc
Collaborators
Novartis
Study Sponsor
Jan D Blankensteijn, MD, PhD, Principal Investigator, Amsterdam UMC, location VUmc
Verification Date
December 2014