Brief Title
Biomarkers of Aneurysm Wall Strength
Official Title
Biological and Biochemical Markers of Aneurysm Wall Degradation; Towards Non-Invasive Wall Strength Analysis.
Brief Summary
The purpose of this study is to identify possible in vivo biochemical and biological markers related to aortic wall strength.
Detailed Description
Rupture of an Abdominal Aortic Aneurysm (AAA) is potentially lethal. prophylactic surgical repair is therefore warranted when the risk of rupture exceeds the risk of complications following surgery. Aneurysm rupture occurs when the forces (stress) acting on the aneurysm wall surpass aneurysm wall strength. Information on both wall stress and strength might therefore improve rupture risk assessment and patient selection for prophylactic repair. Although aneurysm wall stress calculations are possible, no in vivo method exists to determine aneurysm wall strength. This study was designed to identify possible biomarkers of aneurysm wall strength
Study Type
Observational
Primary Outcome
Aneurysm wall strength
Secondary Outcome
Extra Cellular Matrix components (Glucoaminoglycans)
Condition
Abdominal Aortic Aneurysm
Study Arms / Comparison Groups
1
Description: Patients scheduled for elective conventional aneurysm repair
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
50
Start Date
June 2007
Completion Date
January 2010
Primary Completion Date
January 2010
Eligibility Criteria
Inclusion Criteria: - Patient scheduled for transabdominal aortic surgery Exclusion Criteria: - Patient characteristics and aneurysm anatomy suitable for endovascular repair - Previous aortic surgery
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
Jan Blankensteijn, 0031-24-3615333, [email protected]
Location Countries
Netherlands
Location Countries
Netherlands
Administrative Informations
NCT ID
NCT00740740
Organization ID
Wallstrength_01
Study Sponsor
Radboud University Medical Center
Study Sponsor
Jan Blankensteijn, Principal Investigator, Radboud University Medical Center
Verification Date
August 2008