Detecting Abdominal Aortic Aneurysms in First Degree Relatives (Adult Offsprings) to AAA Patients (DAAAD)

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Abdominal aortic aneurysm
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Cook – Abdominal aortic aneurysm Cordis Corporation – Abdominal Aortic Aneurysm
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Brief Title

Detecting Abdominal Aortic Aneurysms in First Degree Relatives (Adult Offsprings) to AAA Patients (DAAAD)

Official Title

Detecting Abdominal Aortic Aneurysms in First Degree Relatives (Adult Offsprings) to AAA Patients (DAAAD)

Brief Summary

      The 8-12 fold higher risk for sisters and brothers of patients with Abdominal Aortic
      Aneurysms (AAA) to develop AAA compared to persons in the population is well known in the
      scientific community. Recently the value of the screening program for siblings has been
      analyzed and is shown to be highly cost-efficient, similar to the population based screening
      of 65-year old men for AAA. Most importantly detection of siblings also adresses and includes
      women at risk. The adult offsprings to AAA patient would hypothetically bear the same risk of
      AAA as siblings. This has never been evaluated scientifically due to the practical
      difficulties in tracking the offspring and inviting them to screening at an age when they are
      at risk of AAA-disease. In Sweden, the unique multigeneration registry exists which could
      support such detection, with the possibility to track adult offspring to patients, and
      investigate the true contemporary prevalence in them.

      The DAAAD project aims at investigating the prevalence in adult offspring parallel to
      developing a model for such a selective screening program

Detailed Description

      This project will evaluate four questions

        1. Feasibility of study design; can we evaluate the prevalence of AAA by inviting and
           detecting risk groups in national registries ?

        2. Point prevalence of AAA in a riskgroup of adult offspring to AAA patients as compared to
           a matched control group

        3. Quality of Life in risk groups: measuring HADS, EQ-5D and questionnaire on heredity,
           including their awareness on their risk for AAA

        4. Cost-effectiveness of such a national program based on prevalence and EQ-5D

      This program will evaluate the risk for AAA in adult offspring and also evaluate a highly
      probable effective registry-based detection route. This could be more cost-efficient than any
      other AAA screening program, since the prevalence presumably is very high, and the
      registry-based route could be cheaper than nurse-based detection or incidental screening. The
      ultimate benefit of this program will be a crude reduction of sudden deaths from AAA for
      adult offspring to AAA patients, and this will be specifically impressive for the female
      relatives that are never subjected to any AAA-screening in our country.

Study Type

Observational

Primary Outcome

Prevalence of AAA

Secondary Outcome

 Awareness of hereditability and anxiety levels

Condition

Abdominal Aortic Aneurysm

Intervention

Ultrasound and questionnaire

Study Arms / Comparison Groups

 Adult offspring
Description:  Adult female and male offspring to AAA patients 45-80 years of age at inclusion Children to detected AAA patients. Found in the Multigeneration registry

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Diagnostic Test

Estimated Enrollment

1500

Start Date

October 12, 2020

Completion Date

November 15, 2022

Primary Completion Date

October 1, 2022

Eligibility Criteria

        Inclusion Criteria:

        Adult offspring to registered AAA parent (adult offspring) adult offspring not having a AAA
        parent (Controls)

        -

        Exclusion Criteria:

        Not living in Stockholm below 45 or above 80

Gender

All

Ages

45 Years - 80 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Rebecka Rebecka, professor, ,

Location Countries

Sweden

Location Countries

Sweden

Administrative Informations

NCT ID

NCT04623268

Organization ID

DAAAD

Responsible Party

Principal Investigator

Study Sponsor

Karolinska University Hospital

Collaborators

 Karolinska Institutet

Study Sponsor

Rebecka Rebecka, professor, Principal Investigator, Karolinska Institutet

Verification Date

November 2022