Brief Title
Predictors of AAA Expansion and/or Rupture
Official Title
Noninvasive Assessment of Abdominal Aortic Aneurysm (AAA) Wall Structural Integrity and Inflammation as Predictors of Expansion and/or Rupture
Brief Summary
Eligible subjects in this study will have either a known abdominal aortic aneurysm (AAA) or because they do not have an AAA (control group). The purpose of this research study is to further study, through FEA, changes that occur in the mechanical properties of the aortic wall. The investigator will compare two radiotracers, 18F-FDG and 11C-PBR28 to determine if one provides more useful and reliable information about inflammation. 18F-FDG and 11C-PBR28 are radioactive drugs that will be used for imaging during the PET-CT scan. The investigator will also compare the results describing the mechanical properties of the AAA wall to the degree of inflammation in that wall as determined by PET-CT imaging to define new and better predictors of AAA growth and/or rupture.
Detailed Description
Eligible subjects in this study will have either a known abdominal aortic aneurysm (AAA) or because they do not have an AAA (control group). The aorta serves as the main artery to supply blood flow to the body. It is approximately the size of a garden hose. Due to the effects of high blood pressure (hypertension), atherosclerosis (hardening of the arteries), and tobacco use, the aorta may widen and enlarge to form an aneurysm. An abdominal aortic aneurysm (AAA) is a dilation (enlargement) or ballooning out of a section of blood vessel caused by disease or weakness in the wall of the aorta below the level of the kidney arteries. As an AAA dilates and increases in size, rupture of the AAA may occur. AAA rupture carries a significant risk of death. Currently, aortic size is the primary factor used to assess aortic rupture risk. There are other imaging procedures (imaging modalities) that are being used and developed to assess AAA rupture risk. Finite element analysis (FEA) is a way to study the mechanical properties of the aortic wall, including areas of stress and strength that are used to calculate rupture risk. Positron Emission Tomography (PET) utilizes glucose (a form of sugar) labeled with a radioactivity to look at the metabolic activity and inflammation in the aortic wall. The purpose of this research study is to further study, through FEA, changes that occur in the mechanical properties of the aortic wall. The investigator will compare two radiotracers, 18F-FDG and 11C-PBR28 to determine if one provides more useful and reliable information about inflammation. 18F-FDG and 11C-PBR28 are radioactive drugs that will be used for imaging during the PET-CT scan. The investigator will also compare the results describing the mechanical properties of the AAA wall to the degree of inflammation in that wall as determined by PET-CT imaging to define new and better predictors of AAA growth and/or rupture. The radioactive tracers that are used in this study are 18F-fludeoxyglucose (FDG) and 11C-PBR28 (PBR) which stands for Peripheral Benzodiazepine Receptor. 11C-PBR28 is considered investigational, which means that it has not been approved by the U.S. Food and Drug Administration. FDG is an approved drug by the FDA, however in this study it is considered investigational. Goal: Twenty-four subjects will be recruited for this study. Six control subjects (three males and three females), will be considered. Control subjects will have known atherosclerosis, without aneurysmal disease. Six subjects (three males and three females) with small AAAs (diameter 3.0-4.5cm), six subjects (three males, AAA >5.5cm and three females, AAA >5.0cm) with AAAs that are indicated for treatment, and six subjects (three males and three females) with rapidly expanding AAAs (>0.5cm over 6 months and/or >1.0cm over 12 months) will be considered. Subjects will have blood drawn to perform a genetic test that will look at genes and proteins to determine subject eligibility. Once the blood work is assessed for eligibility, subjects will undergo the PET-CT scan. The imaging will take approximately 3 hours to complete.
Study Phase
Phase 4
Study Type
Interventional
Primary Outcome
Standard uptake value (SUV)
Secondary Outcome
Rupture potential index (RPI)
Condition
Abdominal Aortic Aneurysm (AAA)
Intervention
Assess AAA rupture risk by PET-CTA scans
Study Arms / Comparison Groups
Control Group
Description: Six control subjects (three males and three females) with known atherosclerosis by standard clinical criteria without aneurysmal disease. To assess AAA rupture risk by PET-CTA scans, participants will undergo PET-CT scan using 11C-PBR28 and 18F-fludeoxyglucose (FDG) tracer. Participants will have a blood draw for genetic testing, pregnancy testing if female and creatinine testing.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Drug
Estimated Enrollment
30
Start Date
August 1, 2017
Completion Date
April 30, 2020
Primary Completion Date
April 30, 2020
Eligibility Criteria
Inclusion - All ethnic groups - 45 years of age or older - *Must fit into one of the three following groups: - Control group (atherosclerosis without aneurysmal disease - Small AAA (3-4.5 cm) - Rapidly growing AAA (0.5 cm in 6 months or 1 cm in 12 months) Exclusion - At risk population (cognitively impaired) - Any exclusion for PT-CT (i.e., allergy to contrast) - Any woman planning to become pregnant, suspects pregnancy, pregnant or breastfeeding) - Any greater than normal potential for cardiac arrest - Renal disease (eGFR <60 mg/ml/1.73m2) - Claustrophobic reactions and/or is unable to lie on the exam table for 60 minutes - Significant radiation exposure via other trials or medical testing
Gender
All
Ages
45 Years - N/A
Accepts Healthy Volunteers
No
Contacts
Sean J. English, MD, ,
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT03231397
Organization ID
201702141
Responsible Party
Sponsor
Study Sponsor
Washington University School of Medicine
Study Sponsor
Sean J. English, MD, Principal Investigator, Washington University School of Medicine, St. Louis, MO 63110
Verification Date
May 2020