Brief Title
Abdominal Aortic Aneurysm Surgery and Thrombosis
Official Title
Study of Thrombotic Complications After Abdominal Aortic Aneurysm Surgery With or Without Infection: AAA-IT
Brief Summary
The aim of our study is to evaluate the incidence of post-operative thrombotic complications after abdominal aortic aneurysm surgery in the context of atherosclerosis or infectious aneurysm and its links with preoperative inflammation and hemostasis.
Detailed Description
Abdominal aortic aneurysm (AAA) develops in the context of atherosclerosis or infection (aortitis or mycotic aneurysm). AAA and its surgery are associated with pro-thrombotic modifications of hemostasis, which persists in the post-operative period. Pro-thrombotic reactions occur in the intraluminal thrombus. Inflammatory cells recruitment is mediated by adhesion molecules from the activated endothelium, such as "vascular cell adhesion molecule-1" (VCAM-1), "intercellular adhesion molecule-1" (ICAM-1), P-selectin and E-selectin. In the setting of infection, neutrophil death process occurs, the NETosis, with the liberation of Neutrophil Extracellular Traps (NETs), containing DNA and histones. NETs are associated with thrombosis and various studies have already quantified NETosis biomarkers in plasma from patients with thrombotic disease, such as MPO-DNA (DNA coupled myeloperoxidase). In the clinical perioperative setting, patients with aortitis scheduled for AAA surgery shwoed exhibit thrombotic events. The hypothesize was that patients with aortitis have an inflammatory and hemostatic activation different from patients who develop AAA in atherosclerotic condition, and that inflammation is a risk factor of postoperative thrombotic events.
Study Type
Observational
Primary Outcome
thrombotic events
Secondary Outcome
white blood cells
Condition
Abdominal Aortic Aneurysm
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
30
Start Date
March 6, 2020
Completion Date
April 30, 2021
Primary Completion Date
December 31, 2020
Eligibility Criteria
Inclusion Criteria: - patient >18 years-old; - patient scheduled for AAA surgery by laparotomy in the vascular surgical unit at Bordeaux University Hospital; - patient who gave his/her authorization for the use of its medical data and results of blood analyses performed on residual plasma and results of aortic material analyses Exclusion Criteria: - patient who do not understand the study (not fluently French speaking or unable to give his/her consent); - patient with a pre-existing hemostatic disorder; - patient scheduled for an endovascular surgery and benefiting from a secondary laparotomy
Gender
All
Ages
18 Years - N/A
Contacts
, +33556795628, [email protected]
Location Countries
France
Location Countries
France
Administrative Informations
NCT ID
NCT04325373
Organization ID
CHUBX 2020/07
Responsible Party
Sponsor
Study Sponsor
University Hospital, Bordeaux
Study Sponsor
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Verification Date
March 2020