Brief Title
Sex-specific Differences in AAA Complexity
Official Title
Retrospective Cohort Analysis of Sex-specific Differences in Abdominal Aortic Aneurysm Complexity and Association With Adverse Outcomes
Brief Summary
A retrospective cohort study of computed tomography scans of AAA patients considered for repair, in order to identify sex specific differences in abdominal aortic aneurysm (AAA) metrics and the association between anatomical differences/features of complexity and adverse patient outcome.
Detailed Description
A retrospective cohort study of computed tomography scans of AAA patients considered for repair. The study aims to, firstly, identify sex specific differences in abdominal aortic aneurysm (AAA) metrics utilising manual and automated image processing techniques; and secondly, if numbers are sufficient, explore the association between features of AAA complexity and adverse patient outcome.
Study Type
Observational
Primary Outcome
Sex-specific differences in thrombus burden
Secondary Outcome
Association between anatomical differences and adverse patient outcome for patients receiving operative repair - need for transfusion, risk of vessel injury, ischaemia (bowel or limb), renal injury and re-intervention/endoleak.
Condition
AAA - Abdominal Aortic Aneurysm
Intervention
CTA Aorta
Study Arms / Comparison Groups
Men
Description: Male participants
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Diagnostic Test
Estimated Enrollment
1000
Start Date
July 31, 2022
Completion Date
October 1, 2024
Primary Completion Date
October 1, 2024
Eligibility Criteria
Inclusion Criteria: - All adult patients with AAA receiving assessment +/- primary open or endovascular repair at participating centre from 1/1/2010 to 31/12/2020. - Must have AAA >= 5cm. - Must have CT imaging within 1 year of operation or definitive turn down for treatment. Exclusion Criteria: - Insufficient CT imaging quality (>3mm slices) or lack of CT within 1 year of operation. - Insufficient clinical data to establish risk factors or clinical outcomes. - Ruptured aneurysm, aorto-iliac occlusive disease, isolated iliac aneurysm, penetrating aortic ulcer, dissection, juxta or supra-renal aneurysm. - Secondary repair/not primary treatment decision for AAA repair.
Gender
All
Ages
50 Years - N/A
Accepts Healthy Volunteers
No
Contacts
, ,
Location Countries
United Kingdom
Location Countries
United Kingdom
Administrative Informations
NCT ID
NCT05399706
Organization ID
292985
Responsible Party
Sponsor
Study Sponsor
Imperial College London
Study Sponsor
, ,
Verification Date
June 2022