Brief Title
Aortic Distensibility
Official Title
ECG-Gated Multidetector CT of Aortic Distensibility FAMRI
Brief Summary
Can software be developed to automatically aid in the measurement of abdominal aortic aneurysms, and is there a way to predict future rupture or growth of abdominal aortic aneurysms.
Detailed Description
Hypothesis: ECG-gated multidetector CT and ECG-gated Dual Source CT can be used to create multiple volumetric datasets of the abdominal aorta over the time period of the cardiac cycle, allowing for direct and regional calculations of abdominal aortic distensibility over the entire volume of the abdominal aorta, providing insight into risk of abdominal aortic aneurysm rupture and early large vessel stiffness.
Study Type
Observational
Primary Outcome
In year one, this data will be used to develop pulsatility software and test robustness.
Secondary Outcome
In year two, the time-resolved CT angiographic datasets from each patient will be analyzed to determine peak AAA pulsatility and peak AAA relative pulsatility (to cross-sectional area within the aneurysm).
Condition
Abdominal Aortic Aneurysm
Study Arms / Comparison Groups
1
Description: Aortic aneurysm repair
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
67
Start Date
November 2004
Completion Date
July 2009
Primary Completion Date
July 2009
Eligibility Criteria
Inclusion Criteria: - AAA must be at least 3 cm to a maximum 4.9cm cross-sectional diameter. - BMI 31 or less. - Creatinine results <2.0 and within six months prior to scan. - US patients must have only normal creatinine (0.9 to 1.4) for one year before study visit. - Patients who are originally scheduled for US, who are then subsequently rolled in this study, will have only a ultrasound scan as followup after the initial CTA. Exclusion Criteria: - Creatinine > 2.0. - Creatinine <0.9 or >1.4 for those who are scheduled for US. - Atrial fibrillation or other arrythmia. - Known AAA greater than 5 cm in size. - Allergy to contrast dye.
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
Joel G. Fletcher, M.D., ,
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT00587977
Organization ID
1994-04
Secondary IDs
2A3360
Study Sponsor
Mayo Clinic
Collaborators
Flight Attendant Medical Research Institute
Study Sponsor
Joel G. Fletcher, M.D., Principal Investigator, Mayo Clinic - Rochester, Minnesota
Verification Date
November 2012