Brief Title
Water- and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease
Official Title
Water-and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease, Evaluated by the Excretion of Aquaporin-2 and Epithelial Sodium Channels in the Urine
Brief Summary
The purpose of the study is to determine whether the excretion of renal water- and salt-channels in the urine reflects the handling of water and salt in the kidneys, and whether the excretion can be used to monitor and/or predict the effects of treatment of certain heart or lung diseases.
Detailed Description
The purpose of the study is to determine whether the excretion of renal water- and salt-channels (Aquaporin-2 and Epithelial Sodium Channels) in the urine accurately reflects the handling of water and salt in the distal tubules af the kidneys, and whether quantification of these channels in the urine is useful to monitor and/or predict the effects of pharmacologic or surgical treatment of Heart Failure and heart failure-related diseases (Aortic stenosis, acute and chronic ischemic heart disease or pulmonary hypertension)
Study Type
Observational
Primary Outcome
Differences in excretion of Aquaporin-2 in urine
Secondary Outcome
Differences in excretion of Epithelial Sodium Channels in urine
Condition
Healthy Volunteers
Intervention
Pharmacologic and mechanical heart failure treatment
Study Arms / Comparison Groups
1
Description: Healthy volunteers
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Drug
Estimated Enrollment
150
Start Date
February 2009
Completion Date
February 2012
Primary Completion Date
February 2012
Eligibility Criteria
Inclusion Criteria: - Symptomatic heart failure - Severe valvular aortic stenosis - Acute Coronary Syndrome - Medically refractory chronic angina pectoris or pulmonary hypertension with preserved left ventricular function Exclusion Criteria: - Pregnancy - Drug abuse - Malignant disease - Significant disease of other organs including endocrine diseases
Gender
All
Ages
30 Years - 80 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Ole Nyvad, M.D., +45 76362257, [email protected]
Location Countries
Denmark
Location Countries
Denmark
Administrative Informations
NCT ID
NCT00830726
Organization ID
S-20080141
Study Sponsor
Kolding Sygehus
Collaborators
Regionshospitalet Holstebro, Holstebro, Denmark
Study Sponsor
Ole Nyvad, M.D., Principal Investigator, Kolding Hospital, Kolding, Denmark
Verification Date
June 2011