Brief Title
Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease
Official Title
Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease: Dual-source Computed Tomography Compared With Invasive Coronary Angiography and Transthoracic Echocardiography
Brief Summary
We sought to determine whether the dual-source computed tomography assessment of aortic valve stenosis and coronary artery disease is equivalent to or even better than conventional invasive coronary angiography and transthoracic echocardiography.
Detailed Description
Until now invasive coronary angiography has established itself for the assessment of symptomatic aortic valve stenosis. Literature shows a good correlation between MSCT, MRI, TTE and TEE for evaluating the severity of the aortic valve stenosis. The dual-source computed tomography (DSCT) is capable of assessing coronary arteries with a high sensitivity and specificity in term of relevant stenosis (>50%), due to its excellent spatial and temporal resolution. This study includes the assessment of patients with symptomatic valve stenosis. The severity of the aortic valve stenosis is being assessed by DSCT and TTE. Significant coronary artery stenosis and its localisation are assessed by DSCT and invasive coronary angiography. We examine the correlation between DSCT on one side and either TTE or invasive coronary angiography on the other.
Study Type
Interventional
Primary Outcome
Quality of cardiac imaging in computed tomography
Condition
Aortic Valve Stenosis
Intervention
DSCT, TTE
Study Arms / Comparison Groups
AVS, CAD
Description: DSCT
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Other
Estimated Enrollment
65
Start Date
May 2007
Primary Completion Date
December 2013
Eligibility Criteria
Inclusion Criteria: - Patients with aortic valve disease who were scheduled to undergo cardiac surgery Exclusion Criteria: - Hemodynamic instability - Renal insufficiency (serum creatinine level > 133umol/L) - Known allergy to iodinated contrast agents - Non-treated hyperthyreosis
Gender
All
Ages
40 Years - N/A
Accepts Healthy Volunteers
No
Contacts
Paul Erne, MD, ,
Location Countries
Switzerland
Location Countries
Switzerland
Administrative Informations
NCT ID
NCT00767013
Organization ID
Cardiac imaging DSCT
Responsible Party
Principal Investigator
Study Sponsor
Luzerner Kantonsspital
Study Sponsor
Paul Erne, MD, Principal Investigator, Luzerner Kantonsspital
Verification Date
April 2013