Brief Title
GPx Activity in Subjects With Aortic Stenosis Undergoing TAVR
Official Title
Glutathione Peroxidase Activity in Subjects With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.
Brief Summary
The aim of this project is to investigate the association of glutathione peroxidase (GPx) and severe aortic stenosis (AS), as well as the impact of transcatheter aortic valve replacement (TAVR) on GPx activity post-procedure. The burden of oxidative stress will be determined by the measurement of GPx, superoxide dismutase (SOD) and lipoprotein A (Lp(a)). We hypothesize GPx activity is reduced in participants with severe AS vs control groups and GPx activity is to increase after TAVR is performed.
Study Type
Observational
Primary Outcome
Level of GPx in blood samples
Condition
Glutathione Peroxidase Activity
Intervention
Blood draw to measure GPx activity
Study Arms / Comparison Groups
Patients with severe aortic stenosis undergoing TAVR
Description: GPx activity levels will be measured on the day of TAVR procedure, the day of discharge, 1 month, and 6 months after the procedure
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Diagnostic Test
Estimated Enrollment
80
Start Date
November 2020
Completion Date
February 2021
Primary Completion Date
February 2021
Eligibility Criteria
Inclusion Criteria: - Age >18 years - Patients with severe AS including participants with low flow, low gradient severe AS and paradoxical severe AS - Patients meeting criteria for TAVR procedure Exclusion Criteria: - Previous aortic valve replacement (surgical or TAVR) - Participants undergoing chemotherapy - End stage liver disease/cirrhosis (liver produces GSH)
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Chinelo Udemgba, MD, 601-870-0143, [email protected]
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT04268160
Organization ID
IRB201902486
Responsible Party
Sponsor
Study Sponsor
University of Florida
Study Sponsor
Chinelo Udemgba, MD, Principal Investigator, University of Florida
Verification Date
October 2020