Brief Title
Concentration of Plant Sterols in Serum and Aortic Valve Cusps
Official Title
Concentrations of Plant Sterols in Serum and Aortic Valve Cusps: a Prospectiv Observational Study
Brief Summary
This study investigates the effect of margarines supplemented with plant sterol esters on serum and cardiovascular tissue concentrations of plant sterols. We assume that consumption of margarine supplemented with plant sterol esters increases serum and cardiovascular tissue concentrations of plant sterols (sitosterol; campesterol).
Detailed Description
The role of plant sterols in cardiovascular diseases is controversially debated. There is an increasing body of evidence that indicates that increased plant sterol serum concentrations are correlated with an increased cardiovascular risk. Functional foods such as margarines supplemented with plant sterol esters are advertised to patients with hypercholesterolemia. Numerous studies show that margarines supplemented with plant sterol esters reduce serum cholesterol concentrations significantly. However, there are no studies available investigating relevant clinical endpoints. Nor are there any studies availabe investigating the effect of the consumption of margarines supplemented with plant sterol esters on serum and cardiovascular tissue concentrations. This study is done to investigate the effect of margarines supplemented with plant sterol esters on serum and cardiovascular tissue concentrations.
Study Type
Observational
Condition
Aortic Valve Stenosis
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
100
Start Date
September 2003
Completion Date
September 2005
Eligibility Criteria
Inclusion Criteria: aortic valve stenosis - Exclusion Criteria:familial hypercholesterolemia. -
Gender
All
Ages
N/A - N/A
Accepts Healthy Volunteers
No
Contacts
Michael Bohm, Professor, 0049-(0)68411623372, [email protected]
Location Countries
Germany
Location Countries
Germany
Administrative Informations
NCT ID
NCT00222950
Organization ID
Plant Sterols 159/04
Secondary IDs
159/04
Study Sponsor
University Hospital, Saarland
Study Sponsor
Michael Bohm, Professor, Principal Investigator, University of the Saarland
Verification Date
September 2005