Brief Title
Endothelial Progenitors in Aortic Stenosis: Association With Aortic Stenosis Progression and Severity
Official Title
Endothelial Progenitors in Aortic Stenosis: Association With Aortic Stenosis Progression, Severity, Symptoms and Left Ventricular Function Assessed by 2D Strain Echocardiography
Brief Summary
There is a correlation between endothelial progenitor cells (stem cells) and stenosis of the aortic valve.
Detailed Description
Degenerative aortic valve (AV) stenosis (AS) is the most common valvular disease and increases in prevalence with age. Severe aortic valve stenosis accounts for considerable disease and death, especially in older patients. Aortic valve stenosis is the primary indication for valve replacement in western countries, and the number will only increase as elderly people are a growing subpopulation. Measures to identify AV disease earlier, to identify factors that influence disease progression and treat AV disease pharmacologically or with less invasive approaches would be a significant improvement over the current standard of care. These advances will only be possible with a better understanding the mechanisms underlying valve development and disease. Preliminary data suggest a novel pathophysiological concept for impaired valvular endothelial cells regeneration, leading to the progression of age-associated calcific AV disease and a potential treatment target is the disrupted endothelial cell layer of the valve leaflet. The research objectives are: 1. To assess the number and function of endothelial progenitor cellss and apoptotic endothelial progenitor cellss in patients with mild, moderate and severe aortic stenosis. 2. To study the association between aortic stenosis progression, severity, symptoms and left ventricular function and the number and function of circulating endothelia progenitor cells. By understanding the correlation between valve severity, left ventricular longitudinal function and endothelial progenitor cells we will indentify high risk patients population that need early intervention. We hope to add new information on the pathogenesis of aortic stenosis and to indentify factors that predict disease progression.
Study Phase
Phase 4
Study Type
Interventional
Primary Outcome
Cardiac death or need for intervantion in correlation to endothelial progenitor cells
Condition
Aortic Stenosis
Intervention
Blood test
Study Arms / Comparison Groups
Aortic setnsosi
Description: blood test
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Other
Estimated Enrollment
200
Start Date
July 2011
Completion Date
June 2014
Primary Completion Date
February 2014
Eligibility Criteria
Inclusion Criteria: - Patients with Aortic stenosis - Control with aortic stenosis Exclusion Criteria: - No
Gender
All
Ages
18 Years - 92 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Sara Shimoni, MD, 972-505759131, [email protected]
Location Countries
Israel
Location Countries
Israel
Administrative Informations
NCT ID
NCT02060071
Organization ID
kap118711ctil
Responsible Party
Principal Investigator
Study Sponsor
Kaplan Medical Center
Study Sponsor
Sara Shimoni, MD, Principal Investigator, Kaplan Medical
Verification Date
February 2014