Prevalence and Significance of Mutations in Genes Encoding NaPi-co-transporters in the Development of CAVD

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Valve 18F System for the Treatment of Patients With Severe Aortic Stenosis Determination of the Acute Effects of Aortic Stenosis on Coronary Artery Haemodynamics Mechanism of Decompensation Evaluation – Aortic Stenosis Speckle Tracking Imaging in Patients With Low Ejection Fraction Aortic Stenosis (SPArKLE-AS) A Comparison of Advanced Imaging Techniques in Aortic Stenosis Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis Microparticles in Severe Aortic Stenosis Aortic Stenosis and PhosphodiEsterase iNhibition With Aortic Valve Replacement (ASPEN-AVR): A Pilot Study An Investigational Drug on Clinical Outcomes in Patients With Aortic Stenosis (Narrowing of the Major Blood Vessel of the Heart)(MK-0653A-043 AM4)(COMPLETED) Clinical Evaluation of MDT-2111 in Subjects With Symptomatic Severe Aortic Stenosis Acute Hemodynamic Effects of Sildenafil in Patients With Severe Aortic Stenosis Transapical Transcatheter Treatment Versus Conventional Surgery in Patients With Native Aortic Valve Stenosis Measurement of Myocardial Stiffness Using Elastometry in Patients With Aortic Stenosis Study to Improve Outcomes in Aortic Stenosis Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study) Severe Aortic Stenosis in Patients Referred for Valve Surgery Frailty and Mortality in Older Old With Severe Aortic Stenosis Myocardial Efficiency of the Left Ventricle in Asymptomatic Patients With Aortic Valve Stenosis – a Prognostic Marker and a Target for Intervention? PCSK9 Inhibitors in the Progression of Aortic Stenosis Early Surgery Versus Conventional Treatment in Very Severe Aortic Stenosis Randomized Study to Evaluate the Efficacy of Fluvastatin on Inflammatory Markers in Patients With Aortic Stenosis. A Comparison of Transcatheter Heart Valves in High Risk Patients With Severe Aortic Stenosis: The CHOICE Trial Angiogenesis and Fibrosis in Aortic Stenosis Acquired Von Willebrand Syndrome in Severe Aortic Stenosis Effect of Bisoprolol on Progression of Aortic Stenosis Use of Cardiac-MRI to Predict Results for People With Severe Aortic Stenosis Effects of Rosuvastatin on Aortic Stenosis Progression Targeting Pulsatile Load to Increase Exercise Capacity and Quality of Life After Aortic Valve Replacement for Severe Aortic Stenosis (PULSE AS) Valvosoft First-In-Man Study in Severe Symptomatic Aortic Stenosis Assessment of Myocardial Tissue Damage in Aortic Stenosis Genetics of Aortic Stenosis: From Family Forms to the Common Forms ACURATE Neo™ Aortic Bioprosthesis for Implantation Using the ACURATE TA™ LP Transapical Delivery System in Patients With Severe Aortic Stenosis ACURATE Neo™ TA Delivery System in Patient With Severe Aortic Stenosis Genetic of Aortic Valve Stenosis – Clinical and Therapeutic Implications The Role of Myocardial Fibrosis in Patients With Aortic Stenosis Morbidity and Mortality Due to Deferral of Aortic Valve Replacement in Patients With Severe Aortic Stenosis Serum Biomarkers for Aortic Valve Stenosis Aortic Stenosis: Determinants of Progression, Severity and Left Ventricular Remodeling Aortic Stenosis in Elderly : Determinant of Progression Biological Variation of Cardiac Biomarkers in Aortic Valve Stenosis GPx Activity in Subjects With Aortic Stenosis Undergoing TAVR Low Flow Low Gradient Aortic Stenosis Relevance of the (re)Search for a Contractile Reserve Vivio AS (Aortic Stenosis) Algorithm Optimization Study Risk Prediction in Aortic Stenosis Acute Haemodynamic Effects of Treatment With Angiotensin Converting Enzyme (ACE)-Inhibitors in Patients With Symptomatic Aortic Stenosis Utility of Exercise-induced N-terminal (NT) Pro-brain Natriuretic Peptide Levels in Predicting Prognosis in Asymptomatic Aortic Stenosis Heart Failure and Aortic Stenosis Transcriptome Valvular Aortic Stenosis: Study of Myocardiac Fibrosis by Magnetic Resonance Imagery Vivio AS (Aortic Stenosis) Detection Study Cardiac MRI for Severe Aortic Stenosis Metabolic Determinants of the Progression of Aortic Stenosis Impact of a Patient Decision Aid for Treatment of Aortic Stenosis Early Detection of Aortic Stenosis in the Community During Flu Vaccination Correlation of Auscultatory Severity of Aortic Stenosis With Trans Thoracic Echocardiography The Effect of Lipitor on Aortic Stenosis

Brief Title

Prevalence and Significance of Mutations in Genes Encoding NaPi-co-transporters in the Development of CAVD

Official Title

Prevalence and Significance of Mutations in Genes Encoding NaPi-co-transporters in the Development of CAVD

Brief Summary

      Mutations in the SLC34A2 gene, that encodes the sodium phosphate co-transporter (NaPi-IIb),
      cause defect cell-uptake of phosphate, which leads to formation of calcium-phosphate
      concretions in the lungs as seen in Pulmonary Alveolar Microlithiasis (PAM). Extra pulmonary
      calcifications, including heart valve calcification, have previously been reported in
      patients with PAM.

      Calcific Aortic Valve Disease (CAVD) is a common disease in the elderly and is characterised
      by thickening and calcification of the aortic valve leaflets in the absence of rheumatic
      heart disease. CAVD is present in more than 25% of patients older than age 65 years and is
      associated with an increased risk of cardiovascular events. Currently, there is no effective
      therapy for the disease other than surgical aortic valve replacement. Both calcium and
      phosphate are the major components of calcific deposits in PAM and CAVD. Based on these
      preliminary findings, the investigators hypothesize that mutations in sodium phosphate
      co-transporters may play a role in both pulmonary and extra pulmonary calcifications.

      Two studies will be performed: 1. A retrospective cross-sectional study including patients
      with an age ≤ 65 years with CAVD from Denmark and Örebro, will be carried out. Genetic
      association analysis will be performed to investigate the incidence of common variants in
      five genes representing sodium phosphate co-transporters (SLC34A1, SLC34A2, SLC34A3, SLC20A1,
      SLC20A2) compared to healthy controls. Associated genes will subsequently be sequenced to
      identify possible causal mutations. 2. In a prospective study, aortic valve tissue will be
      collected from patients with AS undergoing surgical valve replacement. Molecular
      characterisation of the transporters will be conducted by determining the level of specific
      mRNA and protein by RT-PCR/qPCR, and Western Blotting, respectively. The localisation and
      visualisation will be investigated by immunostaining and confocal laser microscopy.
      Fibroblasts and endothelial cells will be isolated and grown in cultures with subsequent
      functional studies of the phosphate uptake.

Study Type

Observational

Primary Outcome

Frequencies of single-nucleotide polymorphisms in genes encoding NaPi co-transporters

Condition

Aortic Valve Calcification

Study Arms / Comparison Groups

 Aortic valve calcification
Description:  Patients with calcific aortic valve disease, age = 65 years or below

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment

600

Start Date

May 2014

Completion Date

April 2019

Primary Completion Date

April 2018

Eligibility Criteria

        Inclusion Criteria:

          -  Aortic valve calcification

          -  Informed consent before study participation

          -  Age: ≥ 18 years ≤ 65 years

        Exclusion Criteria:

          -  Lacking ability to give informed consent

          -  Radiotherapy towards the thorax

          -  Severe kidney disease (in dialysis)

Gender

All

Ages

N/A - 65 Years

Accepts Healthy Volunteers

No

Contacts

Ulf Simonsen, Professor, +45 40513516, [email protected]

Location Countries

Denmark

Location Countries

Denmark

Administrative Informations

NCT ID

NCT02516800

Organization ID

AV-SLC-2014-01

Responsible Party

Sponsor

Study Sponsor

University of Aarhus

Study Sponsor

Ulf Simonsen, Professor, Study Chair, Department of Biomedicine, Aarhus University

Verification Date

May 2017