Brief Title
Three Dimensional Imaging and Wireless Technologies to Enhance Medical Care in Space
Official Title
Multimodality 3D Imaging and Wireless Technologies To Enhance Medical Care in Space
Brief Summary
NASA has outlined the most urgent threats to life and health in manned spaceflight. One of
the threats is the risk of trauma and acute medical problems. One of the most important
provisions of acute and chronic medical services in space is the availability of high quality
diagnostic imaging with the potential for either ground based or onsite interpretation. The
principle diagnostic imaging modality for space crew use in space will be ultrasound. The aim
of the study is as follows:
-To use state of the art 3 dimensional CT scanner to acquire images for segmentation and
registration supplying a template to judge physiologic or pathologic changes observed in
space with 3D ultrasound
Detailed Description
In its Bioastronautics Critical Path Roadmap Baseline Document, NASA has outlined the most
urgent threats to life and health in manned spaceflight currently in need of countermeasures
development. This proposal specifically addresses one of four critical risks directly, that
being the risk of trauma and acute medical problems, ID# 43 in the Clinical Capabilities
discipline area. Critical for the provision of acute and chronic medical services in space is
the availability of high quality diagnostic imaging, with either ground-based or autonomous
interpretation. While development of novel sensor technology is actively pursued within the
NSBRI, it is clear that for the foreseeable future, the principal diagnostic imaging modality
for crew use in space will be ultrasound. For the past six years, the Cleveland Clinic has
worked with NASA and NSBRI in a comprehensive program to develop ultrasonographic
capabilities for use in manned space flight. Recent work has focused on enhancement of these
capabilities, including 3D imaging and novel compression and registration techniques for
assessing change over time in ultrasonic images. We now propose to extend these capabilities
in very significant ways, capitalizing on dramatic recent advances in telecommunications and
computerization to better address the critical countermeasures identified. Among the
convergent trends in ultrasound that we seek to capitalize on are the following: most
commonly applied diagnostic imaging test; Miniaturization; file storage; telemedicine;
wireless telemetry; therapeutic use; real-time 3D.
We propose to extend our work with the following Specific Aims:
1. Extension of our longstanding research in 3D ultrasound with a recently developed third
generation machine small enough to fit on the ISS, allowing more comprehensive imaging
to be done with less operator expertise.
2. Utilization of a ultrafast 3D CT scanner to acquire full body 3D images for segmentation
and registration with subsequently acquired 3D ultrasound images, modelling future
missions for ground-based 3D CT or MRI could provide a template to judge physiologic or
pathologic changes observed in space with 3D ultrasound.
Study Type
Observational
Primary Outcome
To use and compare state-of-the-art 3D CT scanner to acquire 3D images for segmentation and registration with subsequent acquired 3D ultrasound images
Condition
Aortic Valve Insufficiency
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
3
Start Date
June 2003
Completion Date
July 2008
Primary Completion Date
June 2008
Eligibility Criteria
Inclusion Criteria:
- Aortic regurgitation or aortic stenosis and scheduled for repair or replacement
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
Jim D Thomas, MD, ,
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT00598767
Organization ID
NSBRI NCC9-59-172 #2
Responsible Party
Sponsor
Study Sponsor
The Cleveland Clinic
Collaborators
National Space Biomedical Research Institute
Study Sponsor
Jim D Thomas, MD, Principal Investigator, The Cleveland Clinic
Verification Date
January 2008