Brief Title
Genetics of Aortic Stenosis: From Family Forms to the Common Forms
Official Title
Genetics of Aortic Stenosis: From Family Forms to the Common Forms
Brief Summary
The association study will compare the allele frequencies of polymorphisms of a single nucleotide (SNP) in the population of individuals with aortic stenosis compared to a control population. Patients will be included only if they are suffering from a typical form of tight and surgical tricuspid aortic stenosis. Patients will therefore only included if they are suffering from aortic stenosis, the surface is less than 1 cm² and if histological analysis or failing intraoperative findings of the surgeon showed a tricuspid aortic stenosis.
Study Type
Observational
Primary Outcome
identify the genetic factors involved in the occurrence of aortic stenosis
Condition
Aortic Stenosis
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
1987
Start Date
January 2009
Completion Date
December 2013
Primary Completion Date
December 2013
Eligibility Criteria
Inclusion Criteria: 1. Criteria has reached: - That patients are operated or not, they can be considered as having a degenerative aortic stenosis, patients will be diagnosed with aortic stenosis (aortic area <1 cm) without obvious cause found. 2. criteria not met - Strictly normal aortic valve by ultrasound in an over 65-year-old patient. - All patients do not fit into the above two categories are considered as having an unknown phenotype and will not be used in binding assays. In particular, the presence of an aortic sclerosis or even moderate aortic regurgitation can be considered as potentially incipient form of aortic stenosis, patients with this type of anomaly will not be scanned during family analyzes. Exclusion Criteria: - Patients who did not sign the consent - Non degenerative aortic stenosis or for which another cause could be found. Among the most commonly found causes are: - Bicuspid aortic valve - Severe renal impairment - Severe Hypercholesterolemia
Gender
All
Ages
65 Years - N/A
Accepts Healthy Volunteers
No
Contacts
, ,
Location Countries
France
Location Countries
France
Administrative Informations
NCT ID
NCT02890407
Organization ID
PROG/09/61
Responsible Party
Sponsor
Study Sponsor
Nantes University Hospital
Study Sponsor
, ,
Verification Date
September 2016