Brief Title
Tobramycin in Bronchiectasis Colonized With Pseudmonas Aeruginosa
Official Title
Efficacy and Safety of Inhaled Tobramycin on Bronchiectasis Colonized With Pseudomonas Aeruginosa: A Randomized, Double-blind, Parallel-group Multicenter Trial
Brief Summary
This is a phase 3 study. Patients will be enrolled from 14 medical centers in mainland China. Eligible patients will be randomly allocated to treatment group (tobramycin nebulization, 300mg bid) and control group (natural saline nebulization, 5ml bid). A total of two 28-day on-and-off cycles will be scheduled. Both tobramycin solution and natural saline and the nebulizer will be solely provided by the sponsor.
Detailed Description
This is a phase 3 study. All bronchiectasis patients will be enrolled from 14 medical centers located in different geographic regions of mainland China. After a three-week screening period, On the basis of usual care [ambroxool (30mg thrice daily) or N-acetylcysteine (0.2g thrice daily) and chest physiotherapy (5 min, once daily)], eligible patients will be randomly allocated to treatment group (tobramycin nebulization, 300mg bid, delivered via an ultrasonic nebulizer) and control group (natural saline nebulization, 5ml bid, delivered via an ultrasonic nebulizer). A total of two 28-day on-and-off cycles will be scheduled. At the end of each on-and-off cycle, sputum culture and other clinical assessments will be performed.
Study Phase
Phase 3
Study Type
Interventional
Primary Outcome
Changes in sputum load of Pseudomonas aeruginosa at day 29 compared with baseline
Secondary Outcome
The time to the first bronchiectasis exacerbation since randomization
Condition
Bronchiectasis Adult
Intervention
Tobramycin Inhalant Product
Study Arms / Comparison Groups
tobramycin inhalation
Description: 300mg tobramycin dissolved in 5ml saline will be nebulized with an ultrasonic nebulizer within 15-20 minutes.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Drug
Estimated Enrollment
350
Start Date
October 26, 2018
Completion Date
June 2021
Primary Completion Date
April 2021
Eligibility Criteria
Inclusion Criteria: - Aged 18 to 75 years, had a history of chronic cough and sputum production, had physician-diagnosed bronchiectasis based on high-resolution chest computed tomography (effective within 12 months) - Remaining clinically stable (no significant changes in respiratory symptoms and free from upper respiratory tract infection or bronchiectasis exacerbations for 4 weeks) - Sputum culture positive to Pseudomonas aeruginosa at screening - Forced expiratory volume in one second > 30% predicted and < 80% predicted - Could tolerate to nebulization - At least one bronchiectasis exacerbation within the past two years - Can correctly nebulize the study medications and fill in the diary cards following instruction of the investigators Exclusion Criteria: - Had a knwon history of allergy to tobramycin - Had concomitant asthma, allergic bronchopulmonary aspergillosis, active tuberculosis, or active infection with non-tuyberculous mycobacteria that warranted regular anti-mycobacterial treatment - Had moderate or major haemoptysis within 6 months - Had concomitant severe cardiovascular diseases or haematopoietic diseases (congestive heart failure, clinically significant coronary heart disease, myocardial infarction or stroke, clinically arrythmia, known anurysm of the aorta, uncontroll hypertension (systolic blood pressure > 160mmHg or diastolic pressure >100mmHg at two consecutive time points) - Concomitant severe psychiatric disorders - Uncontrolled diabetes mellitus or fasting blood glucose >10mmol/L - Active peptic or duodenal ulcer - Moderate-to-severe gastroesophageal reflux diseases - Malignancy - Severe myasthenia gravis or Parkinson's disease - Major abnormality of hepatic or renal function [ALT or AST >2-fold of the normal upper limit, creatinine > 1.5-fold- greater than the normal upper limit (excluding ALT > 1.5-fold greater than normal upper limit in patients with chronic stable hepatitis)]; concomitant infection with HBV and HCV; - Hearing loss or clinically significant tinittus - Use of inhaled or systemic antibiotics within 4 weeks prior to enrollment - Needing oral or intravenous corticosteroids, or needing systemic corticosteroids within 30 days prior to enrollment - Needing oral or intravenous anti-cholinergic medications, or needing systemic anti-cholinergic medications within 30 days prior to enrollment - Needing long-term non-invasive mechanical ventilation or oxygen therapy (> 10 hrs daily) due to chronic respiratory failure - Pregnancy or lactation - Failure to understand or cooperate with the trial procedures - Participation in other clinical trials within 3 months
Gender
All
Ages
18 Years - 75 Years
Accepts Healthy Volunteers
No
Contacts
Nan-shan Zhong, MD, 13609003622, [email protected]
Location Countries
China
Location Countries
China
Administrative Informations
NCT ID
NCT03715322
Organization ID
GIRH-2018-TOBRA
Responsible Party
Principal Investigator
Study Sponsor
Guangzhou Institute of Respiratory Disease
Study Sponsor
Nan-shan Zhong, MD, Study Chair, The First Affiliated Hospital of Guangzhou Medical University
Verification Date
July 2019