Brief Title
The Prevalence and Impact of Depression and Anxiety Symptoms in Patients With Non-CF Bronchiectasis
Official Title
The Prevalence and Impact of Depression and Anxiety Symptoms in Patients With Non-CF Bronchiectasis
Brief Summary
Patients with chronic diseases are at great risk of depression and anxiety.It is known that
depression and anxiety are one of the most common comorbidities associated with chronic lung
diseases such as asthma and chronic obstructive pulmonary disease.
However,to date,little is known about the rates and risk factors of depression and anxiety
symptoms in non-CF bronchiectasis;and no large-scale prospective studies have been performed
to investigate the effect of depression and anxiety on the healthy outcomes(such as number of
exacerbations and hospitalizations over the ensuing year).Our purpose is to fill these gaps.
Detailed Description
Non-CF bronchiectasis is a long-term condition which affects the lungs.It is characterized by
chronic airway infection with periodic exacerbations which are associated with impaired lung
function, reduced quality of life and increased healthcare costs.Depression and anxiety are
common and are known to be associated with poor quality of life and exacerbations of other
chronic respiratory diseases such as COPD.Studies in COPD have shown that psychological
distress is increasingly elevated and common,with up to 55% of patients suffering from a
clinical diagnosis of anxiety and/or depression;moreover,patients with anxiety and/or
depression were at greater risk for COPD-related exacerbations.Unfortunately,there has been
no systematic evaluation of symptoms of depression and anxiety in patients with non-CF
bronchiectasis or their relationship to health outcomes.A study including 111 non-CF
bronchiectasis patients,O'Leary and colleagues indentified that 34% of patients had elevated
scores for anxiety, depression or both.In a recent study of 93 patients(including 43 with
Cystic fibrosis)of bronchiectasis,20% patients had elevated depression-related scores and 38
% had elevated anxiety-related scores,both depression and anxiety symptoms predicted
significantly worse health-related quality of life.
To date,the studies of depression and anxiety symptoms in patients with non-CF bronchiectasis
have been limited by small samples sizes;and no prospective studies have been conducted to
investigate the impact of psychological distress on the health outcomes.Given the importance
of identifying and treating these symptoms, and their implications for long-term health
outcomes,we plan to determine the prevalence and risk factors of depression and anxiety in
non-CF bronchiectasis.In addition,we investigate the effect of depression and anxiety on the
risk of non-CF bronchiectasis exacerbations and hospitalizations.
Study Type
Observational
Primary Outcome
To evaluate the impact of depression and anxiety symptoms on non-CF bronchiectasis health outcomes.
Secondary Outcome
To estimate the prevalence of anxiety and depression symptoms in patients with non-CF bronchiectasis
Condition
Bronchiectasis
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
160
Start Date
December 2012
Completion Date
May 2014
Primary Completion Date
May 2014
Eligibility Criteria
Inclusion Criteria:
1. Age ≥18 years
2. HRCT diagnosed Bronchiectasis
3. No fever,no worsening of respiratory symptoms,and no medication change within the 4
weeks before recruitment.
4. Capable of providing written informed consent
Exclusion Criteria:
1. cystic fibrosis
2. Previous lung transplantation
Gender
All
Ages
18 Years - 80 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Yongchang Chen, professor, 008615836704735, [email protected]
Location Countries
China
Location Countries
China
Administrative Informations
NCT ID
NCT01688180
Organization ID
Yonghua Gao
Responsible Party
Principal Investigator
Study Sponsor
The First Affiliated Hospital of Guangzhou Medical University
Study Sponsor
Yongchang Chen, professor, Study Director, The First Affiliated Hospital of Guangzhou Medical University
Verification Date
August 2013