The Prevalence and Impact of Depression and Anxiety Symptoms in Patients With Non-CF Bronchiectasis

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Brief Title

The Prevalence and Impact of Depression and Anxiety Symptoms in Patients With Non-CF Bronchiectasis

Official Title

The Prevalence and Impact of Depression and Anxiety Symptoms in Patients With Non-CF Bronchiectasis

Brief Summary

      Patients with chronic diseases are at great risk of depression and anxiety.It is known that
      depression and anxiety are one of the most common comorbidities associated with chronic lung
      diseases such as asthma and chronic obstructive pulmonary disease.

      However,to date,little is known about the rates and risk factors of depression and anxiety
      symptoms in non-CF bronchiectasis;and no large-scale prospective studies have been performed
      to investigate the effect of depression and anxiety on the healthy outcomes(such as number of
      exacerbations and hospitalizations over the ensuing year).Our purpose is to fill these gaps.
    

Detailed Description

      Non-CF bronchiectasis is a long-term condition which affects the lungs.It is characterized by
      chronic airway infection with periodic exacerbations which are associated with impaired lung
      function, reduced quality of life and increased healthcare costs.Depression and anxiety are
      common and are known to be associated with poor quality of life and exacerbations of other
      chronic respiratory diseases such as COPD.Studies in COPD have shown that psychological
      distress is increasingly elevated and common,with up to 55% of patients suffering from a
      clinical diagnosis of anxiety and/or depression;moreover,patients with anxiety and/or
      depression were at greater risk for COPD-related exacerbations.Unfortunately,there has been
      no systematic evaluation of symptoms of depression and anxiety in patients with non-CF
      bronchiectasis or their relationship to health outcomes.A study including 111 non-CF
      bronchiectasis patients,O'Leary and colleagues indentified that 34% of patients had elevated
      scores for anxiety, depression or both.In a recent study of 93 patients(including 43 with
      Cystic fibrosis)of bronchiectasis,20% patients had elevated depression-related scores and 38
      % had elevated anxiety-related scores,both depression and anxiety symptoms predicted
      significantly worse health-related quality of life.

      To date,the studies of depression and anxiety symptoms in patients with non-CF bronchiectasis
      have been limited by small samples sizes;and no prospective studies have been conducted to
      investigate the impact of psychological distress on the health outcomes.Given the importance
      of identifying and treating these symptoms, and their implications for long-term health
      outcomes,we plan to determine the prevalence and risk factors of depression and anxiety in
      non-CF bronchiectasis.In addition,we investigate the effect of depression and anxiety on the
      risk of non-CF bronchiectasis exacerbations and hospitalizations.
    


Study Type

Observational


Primary Outcome

To evaluate the impact of depression and anxiety symptoms on non-CF bronchiectasis health outcomes.

Secondary Outcome

 To estimate the prevalence of anxiety and depression symptoms in patients with non-CF bronchiectasis

Condition

Bronchiectasis



Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

160

Start Date

December 2012

Completion Date

May 2014

Primary Completion Date

May 2014

Eligibility Criteria

        Inclusion Criteria:

          1. Age ≥18 years

          2. HRCT diagnosed Bronchiectasis

          3. No fever,no worsening of respiratory symptoms,and no medication change within the 4
             weeks before recruitment.

          4. Capable of providing written informed consent

        Exclusion Criteria:

          1. cystic fibrosis

          2. Previous lung transplantation
      

Gender

All

Ages

18 Years - 80 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Yongchang Chen, professor, 008615836704735, [email protected]

Location Countries

China

Location Countries

China

Administrative Informations


NCT ID

NCT01688180

Organization ID

Yonghua Gao


Responsible Party

Principal Investigator

Study Sponsor

The First Affiliated Hospital of Guangzhou Medical University


Study Sponsor

Yongchang Chen, professor, Study Director, The First Affiliated Hospital of Guangzhou Medical University


Verification Date

August 2013