Brief Title
The Role of Viral Infection in Acute Exacerbations of Non-cystic Fibrosis Bronchiectasis in Adults
Official Title
The Role of Viral Infection in Acute Exacerbations of Non-cystic Fibrosis Bronchiectasis in Adults
Brief Summary
Bronchiectasis is clinically characterized by irreversible dilation of the bronchi and
bronchioles leading to persistent cough, purulent sputum, and airway flow limitation, which
may be accompanied by recurrent exacerbations.It has been increasingly recognized that
respiratory viruses are mainly responsible for acute exacerbation of chronic pulmonary
diseases, i.e. asthma, chronic obstructive pulmonary disease and cystic fibrosis.
However,little is known about the roles of viral infection in driving exacerbations of
bronchiectasis.This study aims to identify the frequency of common viral infections and
determine the roles that viruses play in acute exacerbations of bronchiectasis.
Detailed Description
Bronchiectasis is a chronic airway disease characterised by a vicious cycle of persistent
bacterial colonization,inflammation and progressive tissue destruction.Patients with
bronchiectasis frequently developed acute exacerbations characterised by acute worsening
requiring changes in concomitant use of medication,with attendant adverse effects on their
morbidity and health-related quality of life. The detailed pathogenesis of exacerbations of
bronchiectasis, however, remains poorly understood.
Recent data suggested that airway infection and inflammation are important drivers of
exacerbations,therefore the imbalance between chronic bacterial infection and host immune
response may result in bronchiectasis exacerbations. Viral infection may be an important
factor that leads to this events.It has been established that respiratory viruses are mainly
responsible for the exacerbations of other chronic respiratory diseases, i.e. asthma, COPD
and cystic fibosis. However, the data regarding prospective studies that sought to
investigate the roles of viruses in acute exacerbation of bronchiectasis are lacking.
Furthermore,the associations between viruses and bacteria during exacerbation need to be
assessed. This study targets at indentifying the frenquency of common viral infections in
adults with non-cystic fibrosis bronchiectasis and may shed light on the effects they have on
clinical parameters,i.e. the length of exacerbated symptom to recovery,lung function,
pulmonary inflammation, bacterial load and quality of life.
Study Type
Observational
Primary Outcome
The prevalence of respiratory virus infection in adults with bronchiectasis during a pulmonary exacerbation and when clinically stable.
Secondary Outcome
The effect of respiratory virus infection on systemic and pulmonary inflammatory markers.
Condition
Bronchiectasis
Study Arms / Comparison Groups
Bronchiectasis,stable
Description: A patient was defined as stable if there was no exacerbation for the previous 4 wk
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
100
Start Date
February 2013
Completion Date
April 2014
Primary Completion Date
April 2014
Eligibility Criteria
Inclusion Criteria:
- Age ≥ 18 years
- HRCT-diagnosed Bronchiectasis
- Capable of providing written informed consent
Exclusion Criteria:
- Patient judged to have poor compliance
- Cystic fibrosis bronchiectasis
Gender
All
Ages
18 Years - 80 Years
Accepts Healthy Volunteers
No
Contacts
Rongchang Chen, MD, 020-83062718, [email protected]
Location Countries
China
Location Countries
China
Administrative Informations
NCT ID
NCT01801657
Organization ID
2009CB522109
Responsible Party
Principal Investigator
Study Sponsor
The First Affiliated Hospital of Guangzhou Medical University
Study Sponsor
Rongchang Chen, MD, Principal Investigator, The First Affiliated Hospital of Guangzhou Medical University
Verification Date
March 2014