Effects of High Intensity Inspiratory Muscle Training on Exercise Capacity in Patients With Bronchiectasis

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Brief Title

Effects of High Intensity Inspiratory Muscle Training on Exercise Capacity in Patients With Bronchiectasis

Official Title

Effects of High Intensity Inspiratory Muscle Training on Exercise Capacity in Patients With Bronchiectasis

Brief Summary

      Reduced exercise tolerance is commonly reported in patients with bronchiectasis. The purpose
      of this study is to evaluate the effects of high-intensity inspiratory muscle training
      (High-IMT) and sham High-IMT (control) on exercise capacity, respiratory muscle function
      (strength and endurance) and health related quality of life in patients with bronchiectasis.
    

Detailed Description

      Bronchiectasis often demonstrates decreased exercise tolerance, marked dyspnea and fatigue.
      The causes are multifactorial and include altered pulmonary mechanics, inefficient gas
      exchange, decreased muscle mass, and psychological status, which all lead to a progressive
      detraining effect. Essentially both the pathology and the functional manifestations of
      bronchiectasis increase the demand for inspiratory muscle work and that contribute to dyspnea
      and exercise limitation.

      In recent studies reduced strength of respiratory muscles are investigated in bronchiectasis
      and can be contribute the exercise limitation. Additionally IMT has shown to improve
      respiratory muscle function, exercise tolerance and dyspnea in patients with bronchiectasis.
      Despite this, the number of studies are inadequate and so the optimal training protocol
      remains still to be defined. In this study the researchers want to investigate the effects of
      high-intensity inspiratory muscle training in functional results in patients with
      bronchiectasis.
    


Study Type

Interventional


Primary Outcome

Exercise capacity using incremental shuttle walk test and 6-minute walk test

Secondary Outcome

 Respiratory muscle strength

Condition

Bronchiectasis

Intervention

Inspiratory muscle training group

Study Arms / Comparison Groups

 High-IMT group
Description:  Intervention group receive supervised training sessions three times per week for 8 weeks. Each sessions lasted 21 minutes and comprised seven cycles of 2 minutes of breathing on an inspiratory threshold device followed by 1 minute of rest. High-IMT was performed at the maximal load tolerable for each 2-minute work interval and was progressively increased over the training period.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Device

Estimated Enrollment

45

Start Date

September 2014

Completion Date

January 5, 2018

Primary Completion Date

December 25, 2017

Eligibility Criteria

        Inclusion Criteria:

          -  diagnosis of bronchiectasis with high resolution computed tomography

          -  being 18-65 years of age

          -  being able to walk and co-operate

        Exclusion Criteria:

          -  acute exacerbation or change in drugs or usage of antibiotics in last 3 weeks

          -  neurological disease, severe orthopaedic problem or advanced heart failure
      

Gender

All

Ages

18 Years - 65 Years

Accepts Healthy Volunteers

No

Contacts

, , 

Location Countries

Turkey

Location Countries

Turkey

Administrative Informations


NCT ID

NCT02656992

Organization ID

GO 13/292


Responsible Party

Principal Investigator

Study Sponsor

Hacettepe University


Study Sponsor

, , 


Verification Date

August 2018