Pain Mechanisms in Patients With Bronchiectasis

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Bronchiectasis
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Brief Title

Pain Mechanisms in Patients With Bronchiectasis

Official Title

Characteristics of Underlying Pain Mechanisms in Patients With Bronchiectasis: a Cross-sectional Study

Brief Summary

      Pain mechanisms and their clinical impact in patients with bronchiectasis have not been
      investigated yet. The aim of the research is to assess the presence of central pain
      mechanisms in patients with bronchiectasis using the Quantitative Sensory Testing (QST)
      assumptions.

Detailed Description

      Background and objective:

      Recent findings suggest that pain can play an important role in terms of physical activity
      limitation in respiratory patients. Nevertheless, pain mechanisms and their clinical impact
      in patients with bronchiectasis have not been investigated yet. The objective of the
      observational study is to determine the somatosensorial profile in order to assess the
      presence of central pain mechanisms in patients with bronchiectasis.

      Methodology:

      Repeated-measures prospective cross-sectional study. A sample of patients diagnosed with
      bronchiectasis will be recruited and matched by age and sex with healthy controls. Pressure
      pain thresholds (PPTs), conditioned pain modulation (CPM) and referral pain will be assessed
      before and after the Incremental Shuttle Walking test (ISW). Levels of physical activity will
      be assessed using accelerometry during a 7-days period. Sleep quality (Pittsburgh sleep
      quality test), level of catastrophizing (Pain Catastrophizing Scale), level of sensitization
      (Central Sensitization Inventory) and level of anxiety and depression (Hospital Anxiety and
      Depression) will be assessed. The assessments will be done twice: 1) at baseline; and 2) at 6
      months follow-up period.

Study Type

Observational [Patient Registry]

Primary Outcome

Referred pain area

Secondary Outcome

 Number of body areas affected by referred pain

Condition

Bronchiectasis

Intervention

No intervention

Study Arms / Comparison Groups

 Adult subjets
Description:  Adult subjets diagnosed with bronchiectasis by high-resolution computed tomography with symptomatology in stable phase, matched by by sex and age with healthy subjects.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Other

Estimated Enrollment

0

Start Date

September 29, 2017

Completion Date

November 30, 2019

Primary Completion Date

October 31, 2019

Eligibility Criteria

        Bronchiectasis Group

        Inclusion Criteria:

          -  Diagnosis of bronchiectasis by high-resolution computed tomography.

          -  Ability to understand and perform all the clinical procedure.

          -  Acquisition of informed consent.

        Exclusion Criteria:

          -  Diagnosis or clinical suspicion of cystic fibrosis by genetic test or sweat
             electrolytes test.

          -  Diagnosis of rheumatic disease.

          -  Being on a waiting list for lung transplantation.

          -  Thoraco-abdominal surgery in the last 6 months.

          -  Chronic use of pain medication.

        Control Group

        Inclusion Criteria:

          -  Healthy subjects matched by age and sex with Bronchiectasis Group's subjects

        Exclusion Criteria:

          -  Be taking pain medication.

          -  Presence of pain condition or pathology.

Gender

All

Ages

18 Years - 90 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

, ,

Location Countries

Spain

Location Countries

Spain

Administrative Informations

NCT ID

NCT03376204

Organization ID

PI17/0290

Responsible Party

Principal Investigator

Study Sponsor

Universidad San Jorge

Study Sponsor

, ,

Verification Date

January 2019