Brief Title
Pulmonary Rehabilitation in Non-Cystic Fibrosis Bronchiectasis
Official Title
Effects of Pulmonary Rehabilitation on Secretion Transport, Inflammation and Respiratory System Strength and Quality of Life in Patients With Bronchiectasis
Brief Summary
The purpose of this study is to assess the effect of pulmonary rehabilitation on the
transport of secretions, inflammation and respiratory resistance, and its repercussions on
the quality of life in patients with bronchiectasis.
Detailed Description
Bronchiectasis is characterized by pathological and irreversible dilation of bronchi caused
by the inefficient removal of secretions and microorganisms and the perpetuation of
inflammatory processes induced by chronic or recurrent infections, causing more damage to the
airways that result in infections, and greater lesion airways and lung parenchyma. Pulmonary
rehabilitation in people with bronchiectasis aims to improve exercise capacity, through
effects on aerobic capacity and peripheral muscles, and to improve disease control and
quality of life. The aim this study is to evaluate the effects of pulmonary rehabilitation on
the transport of secretions, inflammation and respiratory resistance, and its repercussions
on the quality of life in patients with bronchiectasis. In this study 60 volunteers, of both
sexes, aged between 18-60 years, adequate the inclusion criteria, which will be assessed by
lung function tests, the saccharin transport time, the inflammatory markers in the airways,
the respiratory system resistance and quality of life scales. Volunteers will be randomly
divided in pulmonary rehabilitation (PRG) and control groups (CG) that will be subdivided in
bronchiectasis and healthy subgroups. In the PRG group they will receive supervised physical
training twice a week and will be instructed to adopt a routine of home exercises, while CG
will be informed about the benefits of physical activities. All volunteers will be evaluated
after 8 weeks of the baseline and at the end of the research. Data evolution will be
collected from medical records and notes of the medical team and physical therapy that will
follow the routine of these participants
Study Type
Interventional
Primary Outcome
Mucociliary transport in vivo
Secondary Outcome
Mucociliary transport in vitro
Condition
Bronchiectasis
Intervention
Pulmonary Rehabilitation
Study Arms / Comparison Groups
Bronchiectasis Pulmonary Rehabilitation
Description: The volunteers will receive supervised physical training twice a week and will be instructed to adopt a routine of home exercises, for 12 weeks.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Other
Estimated Enrollment
60
Start Date
July 2016
Completion Date
December 2019
Primary Completion Date
July 2018
Eligibility Criteria
Inclusion Criteria:
- clinically stable patients
- both sexes
- aged between 18-60 years
- not due to cystic fibrosis bronchiectasis diagnosis
- non smokers
- no pulmonary disease
Exclusion Criteria:
- asthma or other restrictive conditions
- smokers assets
- decompensated cardiovascular and metabolic diseases, neuromuscular or musculoskeletal
that impede the realization of the Protocol.
Gender
All
Ages
18 Years - 60 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Ada C Gastaldi, PhD, 55 16 33150473, [email protected]
Location Countries
Brazil
Location Countries
Brazil
Administrative Informations
NCT ID
NCT02823587
Organization ID
USP 2016-1
Responsible Party
Principal Investigator
Study Sponsor
University of Sao Paulo
Study Sponsor
Ada C Gastaldi, PhD, Principal Investigator, Ribeirão Preto Medicine School - University of São Paulo
Verification Date
December 2016