Brief Title
Biological Determinants of Sputum Rheology in Chronic Airway Diseases
Official Title
Biological Determinants of Sputum Rheology in Chronic Airway Diseases
Brief Summary
The primary objective of this study is to investigate the biological determinants of sputum rheology variations.
Detailed Description
Secondarily, this study aims to compare rheology parameters between different chronic airway disease sub-populations.
Study Type
Observational
Primary Outcome
Measurement of crossover stress (mucus rheology)
Secondary Outcome
Measurement of the storage modulus (mucus rheology)
Condition
Asthma
Study Arms / Comparison Groups
Asthma
Description: The patients included in this group will have asthma, as specified in the inclusion criteria.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
48
Start Date
September 15, 2019
Completion Date
October 15, 2019
Primary Completion Date
October 15, 2019
Eligibility Criteria
Inclusion Criteria: - Affiliate with or beneficiary of the French national single-payer health insurance system - Patient capable of spontaneous mucus expectoration - Consulting or hospitalized at the study centre Inclusion Criteria for the Asthma Group - Never- or former-smoker (<10 pack-years) - Medical history compatible with asthma - Reversible post-brochodilator (or post-corticosteroid test) ventilatory obstruction (ratio of forced expiratory volume in 1 second : forced vital capacity < 70%) or significant variation in respiratory function -- OR -- Bronchial hyperresponsiveness demonstrated during a broncho-provocation test Inclusion Criteria for the COPD Group - Current- or former-smokers (>10 pack years) - Chronic obstructive pulmonary disease according to GOLD criteria Inclusion Criteria for the Bronchiectasis Group - Presence of bronchiectasis on computed tomography scan - Cystic fibrosis has been ruled out Exclusion Criteria: - Patient expresses opposition to the protocol - Breast feeding or pregnant - Metastatic neoplastic disease - Other active pulmonary disease (tuberculosis, interstitial lung disease) - Recent psychiatric disorder (in the past year and documented via a specialist consult) - Consumption of illicit drugs or alcoholism - Patients in an exclusion period determined by another study - Patients under any type of legal guardianship - Prisoners - Impossible to correctly inform the patient - Does not fluently read French - Emergency situations
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
Mathilde Volpato, MS, ,
Location Countries
France
Location Countries
France
Administrative Informations
NCT ID
NCT04081740
Organization ID
RECHMPL19_0430
Responsible Party
Sponsor
Study Sponsor
University Hospital, Montpellier
Collaborators
APARD Fonds de dotation
Study Sponsor
Mathilde Volpato, MS, Principal Investigator, University Hospitals of Montpellier
Verification Date
November 2019