The Effect of Bronchiectasis on the Exacerbation and Mortality in COPD

Brief Title

The Effect of Bronchiectasis on the Exacerbation and Mortality in COPD

Official Title

The Effect of Bronchiectasis on the Exacerbation and Mortality of Chronic Obstructive Pulmonary Disease

Brief Summary

      Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the airways
      and lungs that develops against harmful particles or gases with exacerbations. Coexistence of
      bronchiectasis with COPD may lead to worsening of the functional parameters as well as
      alteration of the microbiological pattern in exacerbations and may negatively affect the
      exacerbation result parameters.
    

Detailed Description

      Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the airways
      and lungs that develops against harmful particles or gases with exacerbations. COPD
      exacerbations are characterized by worsening of dyspnea, coughing and expectoration.
      Exacerbations requiring hospitalization are the main cause of morbidity and mortality in
      COPD. Bronchiectasis is the irreversible extension of the bronchi. Usually follows with
      chronic sputum cough, airway obstruction and recurrent infection episodes. The association of
      bronchiectasis and COPD has long been known and its incidence is in the range of 30-50%.
      Coexistence of bronchiectasis with COPD may lead to worsening of the functional parameters as
      well as alteration of the microbiological pattern in exacerbations and may negatively affect
      the exacerbation result parameters.
    

Study Type

Observational

Primary Outcome

Charlson Comorbidity Index

Secondary Outcome

 Spirometry

Condition

Bronchiectasis

Intervention

No intervention

Study Arms / Comparison Groups

 COPD exacerbation without Bronchiectasis

Description:  COPD patients who have been in exacerbation period and have no bronchiectasis

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Status

Other

Estimated Enrollment

122

Start Date

January 25, 2010

Completion Date

January 25, 2017

Primary Completion Date

December 25, 2014

Eligibility Criteria

        Inclusion Criteria:

          -  Patients who underwent thoracic tomography in the last year according to index
             exacerbation date were included in the study

        Exclusion Criteria:

          -  Cases that mimic COPD exacerbation (pneumonia, pulmonary thromboembolism, pulmonary
             congestion, pneumothorax, pleural effusion, lung malignancy, asthma, asthma-COPD
             overlap syndrome) and patients admitted to the intensive care unit were excluded from
             the study.
      

Gender

All

Ages

40 Years - 70 Years

Accepts Healthy Volunteers

No

Contacts

Nurdan Kokturk, Professor, , 

NCT ID

NCT03950531

Organization ID

123678

Responsible Party

Principal Investigator

Study Sponsor

Ministry of Health, Turkey

Study Sponsor

Nurdan Kokturk, Professor, Study Chair, Gazi University Faculty of Medicine

Verification Date

May 2019