Brief Title
The Effect of Bronchiectasis on the Exacerbation and Mortality in COPD
Official Title
The Effect of Bronchiectasis on the Exacerbation and Mortality of Chronic Obstructive Pulmonary Disease
Brief Summary
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the airways and lungs that develops against harmful particles or gases with exacerbations. Coexistence of bronchiectasis with COPD may lead to worsening of the functional parameters as well as alteration of the microbiological pattern in exacerbations and may negatively affect the exacerbation result parameters.
Detailed Description
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the airways and lungs that develops against harmful particles or gases with exacerbations. COPD exacerbations are characterized by worsening of dyspnea, coughing and expectoration. Exacerbations requiring hospitalization are the main cause of morbidity and mortality in COPD. Bronchiectasis is the irreversible extension of the bronchi. Usually follows with chronic sputum cough, airway obstruction and recurrent infection episodes. The association of bronchiectasis and COPD has long been known and its incidence is in the range of 30-50%. Coexistence of bronchiectasis with COPD may lead to worsening of the functional parameters as well as alteration of the microbiological pattern in exacerbations and may negatively affect the exacerbation result parameters.
Study Type
Observational
Primary Outcome
Charlson Comorbidity Index
Secondary Outcome
Spirometry
Condition
Bronchiectasis
Intervention
No intervention
Study Arms / Comparison Groups
COPD exacerbation without Bronchiectasis
Description: COPD patients who have been in exacerbation period and have no bronchiectasis
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Other
Estimated Enrollment
122
Start Date
January 25, 2010
Completion Date
January 25, 2017
Primary Completion Date
December 25, 2014
Eligibility Criteria
Inclusion Criteria: - Patients who underwent thoracic tomography in the last year according to index exacerbation date were included in the study Exclusion Criteria: - Cases that mimic COPD exacerbation (pneumonia, pulmonary thromboembolism, pulmonary congestion, pneumothorax, pleural effusion, lung malignancy, asthma, asthma-COPD overlap syndrome) and patients admitted to the intensive care unit were excluded from the study.
Gender
All
Ages
40 Years - 70 Years
Accepts Healthy Volunteers
No
Contacts
Nurdan Kokturk, Professor, ,
Administrative Informations
NCT ID
NCT03950531
Organization ID
123678
Responsible Party
Principal Investigator
Study Sponsor
Ministry of Health, Turkey
Study Sponsor
Nurdan Kokturk, Professor, Study Chair, Gazi University Faculty of Medicine
Verification Date
May 2019