A Prospective Study of Factors Related to Exacerbation and Mortality of Non-cystic Fibrosis Bronchiectasis in Hong Kong

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Brief Title

A Prospective Study of Factors Related to Exacerbation and Mortality of Non-cystic Fibrosis Bronchiectasis in Hong Kong

Official Title

A Prospective Study of Factors Related to Exacerbation and Mortality of Non-cystic Fibrosis Bronchiectasis in Hong Kong

Brief Summary

      Bronchiectasis is associated with repeated exacerbations which occurs at rates of 1.5-6.5 per
      patients per year, and are associated with an increased risk of admission and readmission to
      hospital, and high health care costs. In a local study carried out more than 10 years ago,
      idiopathic disease dominates and patients with bronchiectasis are mainly female with high
      hospitalization and mortality rates; 21.9 cases per 100,000 and 2.7 cases per 100,000
      respectively. Moreover, exacerbation characterized by increases in symptoms requiring
      antibiotic treatment is associated with disease progression and significant mortality.
      Updated prevalence of this disease with the characteristics of etiology, clinical
      presentation and outcomes are needed to guide further management plan.

Study Type

Observational [Patient Registry]

Primary Outcome

Number of bronchiectasis exacerbation

Secondary Outcome

 Mortality rate

Condition

Bronchiectasis Adult

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment

400

Start Date

August 30, 2020

Completion Date

August 29, 2027

Primary Completion Date

August 29, 2027

Eligibility Criteria

        Inclusion Criteria:

          1. Patients aged 18 years or older

          2. Clinically stable for at least 4 weeks prior to enrollment (defined as no symptoms of
             exacerbation, no requirement for supplemental antibiotic therapy)

          3. Diagnosis of bronchiectasis defined by high-resolution computed tomography scan

        Exclusion Criteria:

          1. History of cystic fibrosis; hypogammaglobulinemia; allergic bronchopulmonary
             aspergilosis

          2. Those who are unable to give consent

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

, ,

Location Countries

Hong Kong

Location Countries

Hong Kong

Administrative Informations

NCT ID

NCT04538859

Organization ID

ProBronchiectasis/2019

Responsible Party

Principal Investigator

Study Sponsor

Chinese University of Hong Kong

Study Sponsor

, ,

Verification Date

August 2020