Brief Title
A Prospective Study of Factors Related to Exacerbation and Mortality of Non-cystic Fibrosis Bronchiectasis in Hong Kong
Official Title
A Prospective Study of Factors Related to Exacerbation and Mortality of Non-cystic Fibrosis Bronchiectasis in Hong Kong
Brief Summary
Bronchiectasis is associated with repeated exacerbations which occurs at rates of 1.5-6.5 per patients per year, and are associated with an increased risk of admission and readmission to hospital, and high health care costs. In a local study carried out more than 10 years ago, idiopathic disease dominates and patients with bronchiectasis are mainly female with high hospitalization and mortality rates; 21.9 cases per 100,000 and 2.7 cases per 100,000 respectively. Moreover, exacerbation characterized by increases in symptoms requiring antibiotic treatment is associated with disease progression and significant mortality. Updated prevalence of this disease with the characteristics of etiology, clinical presentation and outcomes are needed to guide further management plan.
Study Type
Observational [Patient Registry]
Primary Outcome
Number of bronchiectasis exacerbation
Secondary Outcome
Mortality rate
Condition
Bronchiectasis Adult
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
400
Start Date
August 30, 2020
Completion Date
August 29, 2027
Primary Completion Date
August 29, 2027
Eligibility Criteria
Inclusion Criteria: 1. Patients aged 18 years or older 2. Clinically stable for at least 4 weeks prior to enrollment (defined as no symptoms of exacerbation, no requirement for supplemental antibiotic therapy) 3. Diagnosis of bronchiectasis defined by high-resolution computed tomography scan Exclusion Criteria: 1. History of cystic fibrosis; hypogammaglobulinemia; allergic bronchopulmonary aspergilosis 2. Those who are unable to give consent
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
, ,
Location Countries
Hong Kong
Location Countries
Hong Kong
Administrative Informations
NCT ID
NCT04538859
Organization ID
ProBronchiectasis/2019
Responsible Party
Principal Investigator
Study Sponsor
Chinese University of Hong Kong
Study Sponsor
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Verification Date
August 2020