Brief Title
Exercise Capacity in Bronchiectasis Resection
Official Title
Impact of Pulmonary Resection on Exercise Capacity in Patients With Bronchiectasis
Brief Summary
Bronchiectasis can be defined as an abnormal and irreversible dilatation of the bronchial
tree due to repeated cycles of inflammation and infection, resulting in progressive loss of
lung function. The surgical treatment by pulmonary resection or even lung transplantation is
indicated in cases of bronchiectasis primary nonresponsive to appropriate medical treatment,
or when associated with serious complications. There are few literature data on the influence
of bronchiectasis in exercise capacity, quality of life and functional capacity, and the
impact of lung resection in patients with this diagnosis. The primary objective of this study
is to evaluate prospectively the impact of lung resection on exercise capacity in patients
with clinical and radiological diagnosis of bronchiectasis. The secondary objective of this
study is to evaluate the impact of lung resection on quality of life and lung function and to
analyze the the presence of predictors of postoperative functional deterioration and the
occurrence of complications.
Study Type
Observational
Primary Outcome
Impact of Pulmonary Resection on Exercise Capacity
Secondary Outcome
Impact of Pulmonary Resection on Quality of Life.
Condition
Bronchiectasis
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
30
Start Date
March 2009
Eligibility Criteria
Inclusion Criteria:
- Clinical and radiographic diagnosis of bronchiectasis;
- Lack of adequate response to clinical treatment after 1 year of follow-up and / or
presence of disease complications;
- Agreement to participate of the study by signing of the Informed Consent Term
Exclusion Criteria:
- Comorbidities that prevent the patient to undergo general anesthesia;
- Musculoskeletal and/or psychomotor disability to perform pulmonary function tests and
cardiopulmonary exercise tests;
- Inability to understand the quality of life questionnaires;
- Age over 90 years or less 18 years.
Gender
All
Ages
18 Years - 90 Years
Accepts Healthy Volunteers
No
Contacts
, 55 11 3069597, [email protected]
Location Countries
Brazil
Location Countries
Brazil
Administrative Informations
NCT ID
NCT01268475
Organization ID
CAPPesq 0671/10
Study Sponsor
University of Sao Paulo
Study Sponsor
, ,
Verification Date
November 2010