Exercise Capacity in Bronchiectasis Resection

Brief Title

Exercise Capacity in Bronchiectasis Resection

Official Title

Impact of Pulmonary Resection on Exercise Capacity in Patients With Bronchiectasis

Brief Summary

      Bronchiectasis can be defined as an abnormal and irreversible dilatation of the bronchial
      tree due to repeated cycles of inflammation and infection, resulting in progressive loss of
      lung function. The surgical treatment by pulmonary resection or even lung transplantation is
      indicated in cases of bronchiectasis primary nonresponsive to appropriate medical treatment,
      or when associated with serious complications. There are few literature data on the influence
      of bronchiectasis in exercise capacity, quality of life and functional capacity, and the
      impact of lung resection in patients with this diagnosis. The primary objective of this study
      is to evaluate prospectively the impact of lung resection on exercise capacity in patients
      with clinical and radiological diagnosis of bronchiectasis. The secondary objective of this
      study is to evaluate the impact of lung resection on quality of life and lung function and to
      analyze the the presence of predictors of postoperative functional deterioration and the
      occurrence of complications.

Study Type

Observational

Primary Outcome

Impact of Pulmonary Resection on Exercise Capacity

Secondary Outcome

 Impact of Pulmonary Resection on Quality of Life.

Condition

Bronchiectasis

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment

Start Date

March 2009

Eligibility Criteria

        Inclusion Criteria:

          -  Clinical and radiographic diagnosis of bronchiectasis;

          -  Lack of adequate response to clinical treatment after 1 year of follow-up and / or
             presence of disease complications;

          -  Agreement to participate of the study by signing of the Informed Consent Term

        Exclusion Criteria:

          -  Comorbidities that prevent the patient to undergo general anesthesia;

          -  Musculoskeletal and/or psychomotor disability to perform pulmonary function tests and
             cardiopulmonary exercise tests;

          -  Inability to understand the quality of life questionnaires;

          -  Age over 90 years or less 18 years.

Gender

All

Ages

18 Years - 90 Years

Accepts Healthy Volunteers

No

Contacts

, 55 11 3069597, [email protected]

Location Countries

Brazil

Location Countries

Brazil

Administrative Informations

NCT ID

NCT01268475

Organization ID

CAPPesq 0671/10

Study Sponsor

University of Sao Paulo

Study Sponsor

, ,

Verification Date

November 2010