Brief Title
The Influence of Anxiety and Depression on Survival in Nasopharyngeal Carcinoma Patients
Official Title
The Influence of Anxiety and Depression on Survival in Nasopharyngeal Carcinoma Patients: a Prospective Observational Cohort Study
Brief Summary
This is a prospective, observational cohort study aimed to explore the influence of anxiety and depression to long term survival in nasopharyngeal carcinoma patients.
Detailed Description
Nasopharyngeal carcinoma (NPC) is endemic in Southern China and Southeast Asia. Radiotherapy (RT) and chemotherapy are the mainstays of therapy for NPC because these tumors are biologically highly radiosensitive and chemosensitive. Anxiety and depression symptoms were common psychological symptoms around the time of cancer diagnosis and were often persistent during cancer treatment. Psychological symptoms are associated with prolonged hospital stays, lower quality of life, and worse treatment adherence among patients with cancer. Depressive symptoms have been demonstrated to predict early mortality among patients with some kinds of cancer. But among NPC patients, the influence of anxiety and depression symptoms to long term survival have not be explored. Therefore, this prospective, observational cohort study aimed to explore the influence of anxiety and depression to long term survival in NPC patients.
Study Type
Observational
Primary Outcome
Progress-free survival
Secondary Outcome
Anxiety related measure
Condition
Nasopharyngeal Carcinoma
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
1000
Start Date
August 20, 2017
Completion Date
September 20, 2022
Primary Completion Date
September 20, 2022
Eligibility Criteria
Inclusion Criteria: - Patients with newly histologically confirmed non-keratinizing nasopharyngeal carcinoma, including WHO II or III - Age between 18-70 - Male and no pregnant female - Patient have signed on the informed consent, and well understood the objective and procedure of this study Exclusion Criteria: - The presence of uncontrolled life-threatening illness - Pregnancy or lactation - Patient with severe medical condition
Gender
All
Ages
18 Years - 70 Years
Accepts Healthy Volunteers
No
Contacts
, 8620-8734-3380, [email protected]
Location Countries
China
Location Countries
China
Administrative Informations
NCT ID
NCT03290001
Organization ID
anxiety and depression
Responsible Party
Principal Investigator
Study Sponsor
Sun Yat-sen University
Study Sponsor
, ,
Verification Date
November 2017