Evaluating Endostatin Plus TC Regimen in Secondary Malignant Neoplasm of Liver Using Contrast Enhancement Ultrasonography

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Trail Evaluating Carbon Ion Radiotherapy (3 GyE Per Fraction) for Locally Recurrent Nasopharyngeal Carcinoma Intestinal Flora Sequencing for Nasopharyngeal Carcinoma Trial Evaluating Carbon Ion Radiotherapy With Concurrent Chemotherapy for Locally Recurrent Nasopharyngeal Carcinoma Study of Cetuximab in Nasopharyngeal Carcinoma (NPC) With Chemoradiotherapy Molecular Genetics Study of Nasopharyngeal Carcinoma: Characterization of NCP Susceptibility Gene(s) Induction Chemotherapy of TPX in Nomogram-predicted High Risk Locoregionally Advanced Nasopharyngeal Carcinoma Apatinib Combined With PD-1 in the Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma Induction Chemotherapy With GP Versus TPF in the Treatment of Advanced Nasopharyngeal Carcinoma Late-Course Accelerated Hyperfractionated IMRT for Locoregionally Advanced Nasopharyngeal Carcinoma Induction Chemotherapy With Nab-paclitaxel, Cisplatin and Fluorouracil for Locoregionally Advanced Nasopharyngeal Carcinoma Phase III 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Nivolumab + Chemoradiation in Stage II-IVB Nasopharyngeal Carcinoma (NPC) Swallowing Exercises for Nasopharyngeal Cancer After Radiation Therapy IMRT Plus Cisplatin Versus IMRT in Patients With Stage 2 Nasopharyngeal Carcinoma Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma TOMO Versus IMRT in Nasopharyngeal Carcinoma Patients TPC vs PF as Induction Chemotherapy Combined With CCRT for Stage IVa-b Nasopharyngeal Carcinoma The Role of Induction Gemcitabine and Cisplatin in Locoregionally Advanced Nasopharyngeal Carcinoma in the Era of IMRT Phase 1/2a Study of VK-2019 in Patients With Epstein-Barr Virus (EBV)-Positive Nasopharyngeal Carcinoma (NPC) Study of Cytolytic Viral Activation Therapy (CVAT) for Recurrent/Metastatic Nasopharyngeal Carcinoma Elimination of Adjuvant Chemotherapy for Selected Stage II and III Nasopharyngeal Carcinoma SOX as Salvage Treatment in Nasopharyngeal Carcinoma Combination of Gemcitabine and Carboplatin in Metastatic or Recurrent Nasopharyngeal Carcinoma A Multicenter Trial Comparing Multi-course Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma A Trial of Adjuvant Chemotherapy in Nasopharyngeal Carcinoma Patients With Residual Epstein-Barr Virus (EBV) DNA Following Radiotherapy De-escalation Protocols in Locoregionally Advanced Nasopharyngeal Carcinoma Concurrent Chemoradiotherapy With Nedaplatin Versus Cisplatin in Nasopharyngeal Carcinoma Ifosfamide and Doxorubicin in Patients With Refractory Nasopharyngeal Carcinoma Two Cycles Versus Three Cyclle of CCRT for Low Risk Locoregionally Advanced Nasopharyngeal Carcinoma Sufficient Chemotherapy Combine With Maintenance Chemotherapy in the Treatment of Oligometastatic Nasopharyngeal Carcinoma Induction Chemotherapy Followed by Concurrent Radiation With Cetuximab or Cisplatin in Locally Advanced Nasopharyngeal Cancer Demethylated Drug in the Treatment of Nasopharyngeal Carcinoma A Phase Ib Trial of MVA-EBNA1/LMP2 Vaccine in Nasopharyngeal Carcinoma To Evaluate the Efficacy of ZOMETA® in Treatment of Bone Metastases in Patients With Stage IV Nasopharyngeal Cancer Study of Neoadjuvant Gemcitabine and Cisplatin in Locoregionally Advanced Nasopharyngeal Carcinoma Donafenib Monotherapy for Previously Treated Metastatic Nasopharyngeal Carcinoma Positron Emission Tomography Scanning and Epstein-Barr Virus DNA Levels in the Staging and Follow-up of Nasopharyngeal Carcinoma. 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Brief Title

Evaluating Endostatin Plus TC Regimen in Secondary Malignant Neoplasm of Liver Using Contrast Enhancement Ultrasonography

Brief Summary

      Contrast enhancement ultrasonography（CEUS）could be used to evaluate the blood flow perfusion
      liver cancer. In this clinical trial, CEUS was used to evaluated the changes of blood flow
      perfusion of Secondary Malignant Neoplasm of Liver after treated with endostatin plus
      paclitaxel and carboplatin regimen.

Study Phase

Phase 2

Study Type

Interventional

Primary Outcome

The changes of blood flow perfusion in secondary malignant neoplasm of liver

Secondary Outcome

 Comparing the difference of OS(Overall Survival) and ORR(Objective Response Rate) according to Response Evaluation Criteria in Solid Tumors (RECIST) criteria in the two different arms.

Condition

Non Small Cell Lung Cancer

Intervention

Paclitaxel , carboplatin, endostatin

Study Arms / Comparison Groups

 Test group
Description:

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Drug

Estimated Enrollment

40

Start Date

January 2011

Completion Date

October 2014

Primary Completion Date

May 2014

Eligibility Criteria

        Inclusion Criteria:

          -  Histologic diagnosis of nasopharyngeal carcinoma or NSCLC

          -  With an evaluable secondary malignant neoplasm of Liver, diameter≥2cm

          -  Without transcatheter arterial chemoembolization (TACE) treatment

          -  Performance status of 0 to 1 on the Eastern Cooperative Oncology Group (ECOG) Scale.

          -  Estimated life expectancy of at least 3 months

          -  Patient compliance and geographic proximity that allow adequate follow-up.

          -  Adequate organ function including the following: Bone marrow: absolute neutrophil
             count (ANC) >or= 1.5x10^9/L, platelets >or= 100x10^9/L, hemoglobin >or= 9g/dL.
             Hepatic: bilirubin <1.5 x ULN, alkaline phosphatase, aspartate transaminase (AST) and
             alanine transaminase (ALT) < 2.5 x ULN (alkaline phosphatase, AST, ALT < 5 x ULN is
             acceptable if liver has tumor involvement). Renal: calculated creatinine clearance >
             45 ml/min.

          -  Men or women of at least 18 years of age.

          -  Signed informed consent from patient.

        Exclusion Criteria:

          -  Women who are pregnant or in lactation

          -  Systemic treatment for another cancer within the year prior to study entry

          -  Known hypersensitivity to any of the study drugs or to drugs with similar chemical
             structures

          -  Use of investigational agents within 28 days of the Baseline visit, or participating
             simultaneously in any other clinical studies

          -  Severe co-morbidity of any type that may interfere with assessment of the patient for
             the study

Gender

All

Ages

18 Years - 70 Years

Accepts Healthy Volunteers

No

Contacts

Li Zhang, ,

Location Countries

China

Location Countries

China

Administrative Informations

NCT ID

NCT01347424

Organization ID

XIANSHENG

Responsible Party

Principal Investigator

Study Sponsor

Sun Yat-sen University

Study Sponsor

Li Zhang, Principal Investigator, Cancer Center of Sun Yat-Sen University (CCSU)

Verification Date

November 2010