Brief Title
Intestinal Flora Sequencing for Nasopharyngeal Carcinoma
Official Title
Intestinal Flora Disruption and a Novel Intestinal Biomarker Associated With Nasopharyngeal Carcinoma
Brief Summary
This study investigated the correlation between the changes in the intestinal flora and NPC by an examination of the intestinal flora and multiple clinical indicators of the blood of 8 carefully screened patients of familial NPC, 24 patients of sporadic NPC and 27 healthy controls and a comparison of the differences in their intestinal flora structures and biological functions. By analyzing the function of the intestinal floras of NPC patients, we aimed to provide a better biological marker for patients with familial and sporadic NPC and constructed a disease prediction model for high-risk populations.
Detailed Description
Nasopharyngeal carcinoma (NPC) is a malignant nasopharyngeal disease with a complicated etiology that occurs mostly in southern China. Intestinal flora imbalance is believed to be associated with a variety of organ malignancies. Currently, the relationship between intestinal flora and NPC is not clear, although many studies have shown that intestinal flora can be used as a biomarker for many cancers and to predict cancer. To compare the differences in intestinal flora compositions and biological functions among patients with familial NPC (NPC_F), patients with sporadic NPC (NPC_S) and healthy controls (NOR), we compared the intestinal flora DNA sequencing and hematological testing results between every two groups using bioinformatic methods.
Study Type
Observational
Primary Outcome
family NPC patients
Condition
Nasopharyngeal Carcinoma
Study Arms / Comparison Groups
Nasopharyngeal carcinoma(NPC)
Description: The patients (1) were diagnosed with NPC; 2)18< Age <75.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
568
Start Date
August 1, 2018
Completion Date
May 30, 2019
Primary Completion Date
December 31, 2018
Eligibility Criteria
Inclusion Criteria: - NPC patients with a first degree family history of NPC - NPC patients without any kind of tumor family history Exclusion Criteria: - Informed refusal. - Lack of necessary tests and patient test information is not detailed
Gender
All
Ages
18 Years - 75 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
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Location Countries
China
Location Countries
China
Administrative Informations
NCT ID
NCT04094545
Organization ID
ThirdXiangyaJHY
Responsible Party
Sponsor
Study Sponsor
The Third Xiangya Hospital of Central South University
Study Sponsor
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Verification Date
September 2018