The Function of PA, RBP and TRSF in Malnutrition Detecting and Nutritional Status Monitoring for NPC Patients

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Trail Evaluating Carbon Ion Radiotherapy (3 GyE Per Fraction) for Locally Recurrent Nasopharyngeal Carcinoma Intestinal Flora Sequencing for Nasopharyngeal Carcinoma Trial Evaluating Carbon Ion Radiotherapy With Concurrent Chemotherapy for Locally Recurrent Nasopharyngeal Carcinoma Study of Cetuximab in Nasopharyngeal Carcinoma (NPC) With Chemoradiotherapy Molecular Genetics Study of Nasopharyngeal Carcinoma: Characterization of NCP Susceptibility Gene(s) Induction Chemotherapy of TPX in Nomogram-predicted High Risk Locoregionally Advanced Nasopharyngeal Carcinoma Apatinib Combined With PD-1 in the Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma Induction Chemotherapy With GP Versus TPF in the Treatment of Advanced Nasopharyngeal Carcinoma Late-Course Accelerated Hyperfractionated IMRT for Locoregionally Advanced Nasopharyngeal Carcinoma Induction Chemotherapy With Nab-paclitaxel, Cisplatin and Fluorouracil for Locoregionally Advanced Nasopharyngeal Carcinoma Phase III 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Brief Title

The Function of PA, RBP and TRSF in Malnutrition Detecting and Nutritional Status Monitoring for NPC Patients

Official Title

The Function of Pre-Albumin, Retinol Conjugated Protein and Transferrin in Early Malnutrition Detecting and Nutritional Status Dynamic Monitoring for Local Advanced Nasopharyngeal Carcinoma Patients With Chemoradiotherapy

Brief Summary

      The purpose of this study is to study the function of pre-albumin, retinol conjugated protein
      and transferrin in early malnutrition detecting and nutritional status dynamic monitoring for
      local advanced nasopharyngeal carcinoma patients with chemoradiotherapy.

Study Type

Observational

Primary Outcome

changes of PA/RBP/TRSF

Secondary Outcome

 Change of Body weight

Condition

Nasopharyngeal Carcinoma

Intervention

cisplatin and docetaxel

Study Arms / Comparison Groups

 CCRT±NACT
Description:  Patients treated with neoadjuvant chemotherapy(NC) (cisplatin and docetaxel) and CCRT (cisplatin) , or treated with CCRT only

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Drug

Estimated Enrollment

50

Start Date

September 12, 2017

Completion Date

December 31, 2020

Primary Completion Date

December 31, 2018

Eligibility Criteria

        Inclusion Criteria:

          -  Newly histologic diagnosis of nasopharyngeal carcinoma(WHO II/III)

          -  All genders，range from 18～60 years old

          -  Karnofsky performance status(KPS) ≥ 80

          -  Clinical stage III~IVb(UICC 8th)

          -  Without significant digestive system disease，nutritional and metabolic diseases or
             endocrine disease

          -  Without significant cardiac，respiratory，kidney or liver disease

          -  Not received radiotherapy, chemotherapy and other anti-tumor treatment(including
             immunotherapy)

          -  white blood cell(WBC) count ≥ 4×109/L, neutrophile granulocyte(NE) count ≥ 1.5×109/L,
             Hemoglobin(HGB) ≥ 10g/L, platelet(PLT) count ≥ 100×109/L

          -  alanine aminotransferase (ALT) or aspartate aminotransferase(AST) < 1.5×upper limit of
             normal(ULN), bilirubin < 1.5×ULN, alanine aminotransferase (CCR) ≥ 30ml/min

          -  Inform consent form

        Exclusion Criteria:

          -  Distance metastases

          -  Second malignancy within 5 years

          -  Drug or alcohol addition

          -  Do not have full capacity for civil acts

          -  Active systemic infections

          -  Chronic consumptions

          -  Mental disorder

          -  Pregnancy or lactation

          -  Concurrent immunotherapy or hormone therapy for other diseases

          -  Severe complication, eg, uncontrolled hypertension

Gender

All

Ages

18 Years - 60 Years

Accepts Healthy Volunteers

No

Contacts

, ,

Location Countries

China

Location Countries

China

Administrative Informations

NCT ID

NCT03240835

Organization ID

NPC-PA/RBP/TRSF

Responsible Party

Sponsor-Investigator

Study Sponsor

Zhao Chong

Collaborators

 Wu Jieping Medical Foundation

Study Sponsor

, ,

Verification Date

March 2020