Oligo-metastases NPC Patients Received Radiation for Primary Tumors and Treatments for Metastatic Lesions

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Outcomes in Nasopharyngeal Carcinoma Serial Plasma EBV DNA for Nasopharyngeal Carcinoma Apatinib in Treating Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma (NPC) Induction Chemotherapy in Young Patients With Locoregionally Advanced Nasopharyngeal Carcinoma A Multicenter, Prospective, Phase III Randomized Controlled Clinical Study for the Treatment of N2-3 Nasopharyngeal Carcinoma Patients Phase 2 Trial of Ipilimumab and Nivolumab in Nasopharyngeal Carcinoma A Trial On 4 Cycles Of Neoadjuvant Chemotherapy Plus Concurrent Chemoradiation In N2-3 Nasopharyngeal Carcinoma Effect of Oral Supplements on the Nutritional Status of Locally Advanced Nasopharyngeal Carcinoma Patients Endostar for Locally Recurrent Nasopharyngeal Carcinoma Prospective Study for Prognostic Biomarkers of Nasopharyngeal Carcinoma A Phase II Study of Icotinib in Treating Patients With Advanced Nasopharyngeal Carcinoma Radiation-associated Carotid Artery Disease in Patients With Nasopharyngeal Carcinoma Trail Evaluating Carbon Ion Radiotherapy (3 GyE Per Fraction) for Locally Recurrent Nasopharyngeal Carcinoma Intestinal Flora Sequencing for Nasopharyngeal Carcinoma Trial Evaluating Carbon Ion Radiotherapy With Concurrent Chemotherapy for Locally Recurrent Nasopharyngeal Carcinoma Study of Cetuximab in Nasopharyngeal Carcinoma (NPC) With Chemoradiotherapy Molecular Genetics Study of Nasopharyngeal Carcinoma: Characterization of NCP Susceptibility Gene(s) Induction Chemotherapy of TPX in Nomogram-predicted High Risk Locoregionally Advanced Nasopharyngeal Carcinoma Apatinib Combined With PD-1 in the Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma Induction Chemotherapy With GP Versus TPF in the Treatment of Advanced Nasopharyngeal Carcinoma Late-Course Accelerated Hyperfractionated IMRT for Locoregionally Advanced Nasopharyngeal Carcinoma Induction Chemotherapy With Nab-paclitaxel, Cisplatin and Fluorouracil for Locoregionally Advanced Nasopharyngeal Carcinoma Phase III 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Brief Title

Oligo-metastases NPC Patients Received Radiation for Primary Tumors and Treatments for Metastatic Lesions

Official Title

The Clinical Curative Efficacy and Side Effect of Oligo-metastases Nasopharyngeal Carcinoma Patients Received Radical Radiation for Primary Tumors and Treatments for Metastatic Lesions

Brief Summary

      Oligo-metastases NPC patients received radiation for primary tumors and treatments for
      metastatic lesions.

Detailed Description

      The patients enrolled will received 4-6 cycles chemotherapy at first.Then, radical
      radiotherapy for nasopharyngeal tumors and local treatments for oligometastatic lesions will
      assigned to those patients. The efficacy and side-effect will be evaluated and analyzed.

Study Phase

Phase 2

Study Type

Interventional

Primary Outcome

Overall survival

Secondary Outcome

 Progress free survival

Condition

Nasopharyngeal Cancer

Intervention

radical radiotherapy

Study Arms / Comparison Groups

 Arm 1
Description:  4-6 cycles chemotherapy and radical radiotherapy for primary tumors were given. Appropriate treatments for olio-metastatic lesions will assigned to those who got PR,SD after chemotherapy.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Radiation

Estimated Enrollment

64

Start Date

April 14, 2017

Completion Date

April 23, 2025

Primary Completion Date

April 23, 2023

Eligibility Criteria

        Inclusion Criteria:

          1. Histologically conformed initial non-keratinizing squamous carcinoma in nasopharynx.

          2. Clinical stages,T1-4N0-3M1，IVc(AJCC 2010).

          3. The metastatic lesions ≤5 and metastatic organs ≤2

          4. Karnofsky scores >70

          5. Normal hemodynamic indices before the recruitment (including white blood cell
             count>4.0×109/L, neutrophil count>1.5×109/L, platelet count >100×109/L,
             hemoglobin≥90g/l, normal liver/kidney function).

          6. Informed consent signed.

        Exclusion Criteria:

          1. Histologically conformed initial keratinizing carcinoma or others.

          2. The metastatic lesions >5 or metastatic organs >2.

          3. Any severe complications contraindicated chemotherapy or radiotherapy.

          4. History of malignant tumors.

          5. Pregnant or nursing women.

          6. History of radiotherapy or chemotherpy in head and neck regions.

          7. Patients refused the informed consent.

Gender

All

Ages

18 Years - 65 Years

Accepts Healthy Volunteers

No

Contacts

, +8618258111085, [email protected]

Location Countries

China

Location Countries

China

Administrative Informations

NCT ID

NCT03129412

Organization ID

NPC-Oligo-M

Responsible Party

Sponsor

Study Sponsor

Zhejiang Cancer Hospital

Study Sponsor

, ,

Verification Date

September 2020