The Association of hsCRP and Radiotherapy-Induced Toxicity in Patients With Nasopharyngeal Carcinoma

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Trail Evaluating Carbon Ion Radiotherapy (3 GyE Per Fraction) for Locally Recurrent Nasopharyngeal Carcinoma Intestinal Flora Sequencing for Nasopharyngeal Carcinoma Trial Evaluating Carbon Ion Radiotherapy With Concurrent Chemotherapy for Locally Recurrent Nasopharyngeal Carcinoma Study of Cetuximab in Nasopharyngeal Carcinoma (NPC) With Chemoradiotherapy Molecular Genetics Study of Nasopharyngeal Carcinoma: Characterization of NCP Susceptibility Gene(s) Induction Chemotherapy of TPX in Nomogram-predicted High Risk Locoregionally Advanced Nasopharyngeal Carcinoma Apatinib Combined With PD-1 in the Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma Induction Chemotherapy With GP Versus TPF in the Treatment of Advanced Nasopharyngeal Carcinoma Late-Course Accelerated Hyperfractionated IMRT for Locoregionally Advanced Nasopharyngeal Carcinoma Induction Chemotherapy With Nab-paclitaxel, Cisplatin and Fluorouracil for Locoregionally Advanced Nasopharyngeal Carcinoma Phase III Study of Camrelizumab in Combination With Chemotherapy in Recurrent/Metastatic Nasopharyngeal Carcinoma Docetaxal & Cisplatin vs LDFRT + Docetaxal & Cisplatin in Locally Advanced NPC Aspirin Improve Survival of N2-3 Nasopharyngeal Carcinoma Patients GC Regimen Chemotherapy Plus CIK Cells for Metastatic Nasopharyngeal Carcinoma A Phase III Trial Evaluating Chemotherapy and Immunotherapy for Advanced Nasopharyngeal Carcinoma (NPC) Patients A Phase III Study of Radiotherapy With or Without Adjuvant C/T in Advanced Stage Nasopharyngeal Carcinoma Patients The Value of Concurrent Chemoradiotherapy for Stage II Nasopharyngeal Carcinoma Induction Cisplatin and Capecitabine Followed by Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma Trail Evaluating Carbon Ion Radiotherapy for Locally Recurrent Nasopharyngeal Carcinoma The Value of Single-cycle TPF Induction Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma Effect of Endostar Combined With Intensity-modulated Radiotherapy Compare With Chemoradiation for Locoregionally Advanced,Low-risk Nasopharyngeal Carcinoma Endostar Combined With Induction Chemotherapy and Concurrent Chemoradiotherapy for Locoregional Nasopharyngeal Carcinoma Adjuvant Chemotherapy in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma Induction Chemotherapy in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma A Study of Anti-PD-1 AK105 in Patients With Metastatic Nasopharyngeal Carcinoma Induction Gemcitabine and Cisplatin in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma Induction and Concurrent Chemoradiotherapy With Cetuximab for Patients With Locally Advanced Nasopharyngeal Carcinoma Toripalimab for Local-regional Recurrent Nasopharyngeal Carcinoma Hypofractionated Versus Conventionally Fractionated Radiotherapy for Initial Distant Metastases Nasopharyngeal Carcinoma Foscan®-Mediated Photodynamic Therapy Versus Brachytherapy in Patients With Nasopharyngeal Carcinoma The 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Brief Title

The Association of hsCRP and Radiotherapy-Induced Toxicity in Patients With Nasopharyngeal Carcinoma

Official Title

An Explorative Study on the Association of High Sensitivity C-Reactive Protein (hsCRP) and Radiotherapy-Induced Toxicity in Patients With Nasopharyngeal Carcinoma

Brief Summary

      The primary purpose of this study is to explore the association of high sensitivity
      C-reactive protein (hsCRP) and radiotherapy(RT)-induced toxicity in patients with
      nasopharyngeal carcinoma. In each patient, hsCRP levels in the pre- and post-RT plasma
      samples will be measured according to the schedule we set.

Study Type

Observational

Primary Outcome

hsCRP levels

Condition

Nasopharyngeal Carcinoma

Intervention

clinical measurements

Study Arms / Comparison Groups

 Group 1: Patients with neoadjuvant chemotherapy
Description:  The patients of group1 will receive one of the following treatments:
neoadjuvant chemotherapy & concurrent chemoradiotherapy
neoadjuvant chemotherapy & radiotherapy
neoadjuvant chemotherapy & radiotherapy & adjuvant chemotherapy

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Other

Estimated Enrollment

300

Start Date

June 2021

Completion Date

December 2021

Primary Completion Date

December 2021

Eligibility Criteria

        Inclusion Criteria:

          -  Patients were pathologically newly diagnosed with nasopharyngeal carcinoma and had no
             previous history of other tumors

          -  According to the treatment strategies of doctors, patients need to receive
             radiotherapy with or without chemotherapy (for example, neoadjuvant chemotherapy,
             concurrent chemotherapy, adjuvant chemotherapy) or targeted therapy

          -  Willingness to sign the informed consent and return to enrolling institution for
             follow-up and data collection

        Exclusion Criteria:

          -  Patients do not conform to the inclusion criteria

          -  Pregnant or Nursing women

          -  Men or women of childbearing potential who are unwilling to employ adequate
             contraception

          -  Vital organs dysfunction(for example, kidneys, heart, liver, lungs, brain)

          -  Other contraindications or unsuitable conditions for radiotherapy

Gender

All

Ages

18 Years - 70 Years

Contacts

Jiarong Chen, PhD, 86-0750-3399003, [email protected]

Administrative Informations

NCT ID

NCT04303975

Organization ID

JM0019002

Responsible Party

Sponsor-Investigator

Study Sponsor

Jiarong Chen, MD

Study Sponsor

Jiarong Chen, PhD, Principal Investigator, Affiliated Jiangmen Hospital of Sun Yat-Sen University

Verification Date

June 2020