Applying PET/MR in Oncology – a Prospective Project

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Carcinoma KL-A167 Injection in Recurrent or Metastatic Nasopharyngeal Carcinoma Who Have Received Previous At Least Two Lines of Chemotherapy The Effect of COX-2 Inhibitor on Radiosensitivity in Nasopharyngeal Carcinoma Dietary Nitrate on Salivary Flow for Nasopharyngeal Carcinoma Patients PD-L1 and BRAF Expression in Nasopharyngeal Carcinoma Endostar Combination With Chemotherapy for the Metastatic Nasopharyngeal Carcinoma New Approach of Assessing Drug Response for Treatment of Nasopharyngeal Cancer Dietary Nitrate on Plasma Nitrate Levels for Nasopharyngeal Carcinoma Patients Study to Evaluate Induction Chemotherapy Using Docetaxel, Cisplatin and Fluorouracil in Concurrence With Intensity-modulated Radiotherapy for Local Recurrent Nasopharyngeal Carcinoma (NPC) Serial Epstein-Barr Virus DNA Surveillance in Nasopharyngeal Carcinoma Patients SHR-1210 in Recurrent/Metastatic Nasopharyngeal Carcinoma Who Have Received Previous At Least Two Lines of Chemotherapy. 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Phase Ⅲ Trial of Adjuvant Chemotherapy in Patients With N2-3 Nasopharyngeal Carcinoma TPF+CCRT vs.CCRT+PF in High Risk Nasopharyngeal Carcinoma Nimotuzumab for Recurrent Nasopharyngeal Carcinoma Adjuvant Treatment of Apatinib in Nasopharyngeal Carcinoma Efficacy of Recombinant Epstein-Barr Virus (EBV) Vaccine in Patients With Nasopharyngeal Cancer Who Had Residual EBV DNA Load After Conventional Therapy Therapeutic Gain by Induction-concurrent Chemoradiotherapy and/or Accelerated Fractionation for Nasopharyngeal Carcinoma Screening Nasopharyngeal Carcinoma With EBV Associated Biomarkers in Zhongshan City SHR-1701 in Patients With Recurrent/Metastatic Nasopharyngeal Carcinoma A Study of Gemcitabine and Cisplatin/Carboplatin Plus Erlotinib in Patients With Nasopharyngeal Cancer Swallowing Pattern of Patients With Nasopharyngeal Cancer Before and After Radiation Therapy: Longitudinal Study and Correction With Saliva Amount Safety and Efficacy Study of Icotinib With Intensity-modulated Radiotherapy in Nasopharyngeal Carcinoma Screening for Nasopharyngeal Carcinoma in High Risk Populations EBV-Specific CTLs Following CD45 Antibody to Patients With Epstein-Barr Virus (EBV) + Nasopharyngeal Carcinoma (NPC) Pilot Study of Somatostatin Receptor Imaging in Nasopharyngeal Cancer A Study of Lymphangiogenesis in Colorectal and Nasopharyngeal Cancer PET/MR in Locally Advanced Nasopharyngeal Carcinoma Bortezomib and Gemcitabine in Treating Patients With Recurrent or Metastatic Nasopharyngeal Cancer Maintenance Treatment of Apatinib in Nasopharyngeal Carcinoma Dendritic Cell Therapy With CD137L-DC-EBV-VAX in Locally Advanced Stage IV or Locally Recurrent/Metastatic Nasopharyngeal Carcinoma Weekly Docetaxel Plus Cisplatin as the First-line Therapy for Nasopharyngeal Cancer Nasopharyngeal Carcinoma Screening in Zhongshan City Nasopharyngeal Carcinoma Post IMRT To Investigate the Molecular Mechanism of Traditional Chinese Medicine Constitution Using Next-generation Sequencing in Nasopharyngeal Carcinoma Avelumab for Recurrent/Metastatic Nasopharyngeal Cancer Parotid-sparing IMRT for Nasopharyngeal Cancer Induction Chemotherapy and Chemoradiotherapy in Nasopharyngeal Cancers A Study of Capecitabine (Xeloda) as First-Line Chemotherapy in Participants With Metastatic Nasopharyngeal Cancer Prospective Nasopharyngeal Carcinoma Screening Using Plasma Epstein-Barr Virus DNA Analysis Assessment of Treatment Response of Nasopharyngeal Cancer Using Simultaneous 18F-FDG-PET and MRI HepaSphere Interventional Therapy Using Digital Subtraction Angiography(DSA) for Nasopharyngeal Carcinoma A Study of Xeloda (Capecitabine) in Combination With XELOX (Oxaliplatin) in Patients With Metastatic Nasopharyngeal Cancer. 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Brief Title

Applying PET/MR in Oncology - a Prospective Project

Official Title

Applying PET/MR in Oncology - a Prospective Project

Brief Summary

      Cancer is a global health issue. According to the World Health Organization, Cancer is the
      second leading cause of death globally, and is responsible for an estimated 9.6 million
      deaths in 2018. In Israel, more than 30,000 new cases of cancer were diagnosed, and more than
      11,000 deaths were cancer-related during 2016.

      Imaging plays a pivotal role in cancer management, and multiple techniques are used in all
      phases of cancer management. The overall morphological, structural, metabolic and functional
      information obtained in imaging is used for improved individualized therapy planning.
      Different imaging modalities are available during different time points in the natural
      history of different malignancies:

      Early detection of cancer through screening based on imaging is probably a major contributor
      to a reduction in mortality for certain cancers .

      Once a diagnosis is made, determining the clinical stage of cancer, meaning the extent of the
      disease before any treatment is given, is a critical element in determining appropriate
      treatment based on the experience and outcomes of groups of previous patients with similar
      stage . Precise clinical staging of cancer is crucial. Not only that this clear non-ambiguous
      description is a key factor that defines prognosis, it is also a chief component of
      inclusion, exclusion, and stratification criteria for clinical trials. Several cancer staging
      systems are used worldwide. The most clinically useful staging system is the tumor, node, and
      metastasis (TNM) staging system developed by the American Joint Committee on Cancer (AJCC) in
      collaboration with the Union for International Cancer Control (UICC). The AJCC TNM system
      classifies cancers by the size and extent of the primary tumor (T), involvement of regional
      lymph nodes (N), and the presence or absence of distant metastases (M). There is a TNM
      staging algorithm for cancers of virtually every anatomic site and histology, with the
      primary exception of pediatric cancers. The clinical TNM (cTNM) classification should be used
      to determine correctly the clinical stage of cancer and to help guide primary therapy
      planning.
    

Detailed Description

      Stage may be defined at several time points during the monitoring period of cancer patients.
      When using imaging obtained during the relevant time frame, one may use one of the other TNM
      categories to stage correctly the cancer:

      For example, imaging is of high value in assessing therapy response during and after systemic
      and/or radiation therapy is given . Using imaging data and the clinical posttherapy TNM
      classification (ycTNM) is helpful in determining the patient's response to treatment.

      In case a patient is given the systemic therapy as a neoadjuvant therapy before a planned
      curative surgery, imaging may categorize the patient as a responder vs non-responder. If
      categorized as an early non-responder, another therapy or an upfront surgery may be advised,
      while eliminating therapy toxicity. If imaging, however, supports major response to
      treatment, more conservative treatment and avoidance of surgical intervention may be
      considered and change patients quality of life dramatically.

      In patients given a systemic therapy as a curative or a palliative therapy, assessing the
      response via imaging is crucial as well - if imaging studies support a progressive disease,
      changing therapy protocol is advised. In a disease controlled by the therapy, imaging may aid
      in guiding follow-up schedule, lifestyle and medical management.

      In the context of therapy response assessment, imaging is also important in assessing side
      effects of the therapy. Imaging may identify radiation-induced injuries, and may recognize
      pathologies associated with chemotherapy, biologic and immunotherapy.

      Imaging is also critical when recurrence of malignant disease is suspected. In such cases,
      when signs or symptoms suggest local recurrence, or when raised level of a tumor marker is
      documented, different imaging techniques can dramatically guide restaging of the disease
      using the recurrence-TNM classification (rTNM). In such cases imaging may localize the
      recurrent disease and may guide surgical/radiation/systemic therapy .

      Different imaging modalities allow assessment of virtually every cancer site and in every
      time frame during the continuum of the disease. Imaging aids in assessing tumor's size,
      location, and relationship to normal anatomic structures, as well as the existence of nodal
      and/or distant metastatic disease. Among the most commonly used imaging modalities are
      computed tomography (CT), magnetic resonance (MR) imaging, positron emission tomography (PET)
      and ultrasound. In addition to providing key information for assigning the T, N, and M
      categories, imaging is invaluable for guiding biopsies and surgical resections.

      PET imaging has revolutionized the imaging evaluation of cancer . By exploiting biochemical
      and physiologic differences between tumor cells and normal tissues , PET imaging has become
    


Study Type

Interventional


Primary Outcome

Patients who preformed PET/MR and PET/CT in clinical staging and monitoring of different cancer types will be measured and reported number of Participants in staging and different between their scans/


Condition

Lymphoma

Intervention

PET/MR scan

Study Arms / Comparison Groups

 Different types of cancer Patients
Description:  Lymphoma,Nasopharyngeal Cancer; Esophageal Cancer, Cervical cancer; Hepatobiliary and pancreatic cancer; Sarcoma; Prostate Cancer

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Diagnostic Test

Estimated Enrollment

500

Start Date

November 28, 2019

Completion Date

November 28, 2021

Primary Completion Date

January 28, 2020

Eligibility Criteria

        Inclusion Criteria:

          1. patients diagnosed in One of the cancers being investigated.

          2. Only in Sarcoma:20 children and adults with newly diagnosed sarcomas. Children will be
             included if can perform the study without sedation, and with written parental
             approval.

        Exclusion Criteria:

          1. Patients younger than 18 years.

          2. Pregnancy/

          3. Patients contraindication to MRI or to intravenous gadolinium injection.
      

Gender

All

Ages

18 Years - 120 Years

Accepts Healthy Volunteers

No

Contacts

, , 



Administrative Informations


NCT ID

NCT04158414

Organization ID

TASMC-19-ES-0568-CTIL


Responsible Party

Sponsor

Study Sponsor

Tel-Aviv Sourasky Medical Center


Study Sponsor

, , 


Verification Date

November 2019