Comparison of Transdermal Fentanyl and Morphine for Oral Mucositis Pain in Nasopharyngeal Cancer Patients

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Carcinoma KL-A167 Injection in Recurrent or Metastatic Nasopharyngeal Carcinoma Who Have Received Previous At Least Two Lines of Chemotherapy The Effect of COX-2 Inhibitor on Radiosensitivity in Nasopharyngeal Carcinoma Dietary Nitrate on Salivary Flow for Nasopharyngeal Carcinoma Patients PD-L1 and BRAF Expression in Nasopharyngeal Carcinoma Endostar Combination With Chemotherapy for the Metastatic Nasopharyngeal Carcinoma New Approach of Assessing Drug Response for Treatment of Nasopharyngeal Cancer Dietary Nitrate on Plasma Nitrate Levels for Nasopharyngeal Carcinoma Patients Study to Evaluate Induction Chemotherapy Using Docetaxel, Cisplatin and Fluorouracil in Concurrence With Intensity-modulated Radiotherapy for Local Recurrent Nasopharyngeal Carcinoma (NPC) Serial Epstein-Barr Virus DNA Surveillance in Nasopharyngeal Carcinoma Patients SHR-1210 in Recurrent/Metastatic Nasopharyngeal Carcinoma Who Have Received Previous At Least Two Lines of Chemotherapy. 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Phase Ⅲ Trial of Adjuvant Chemotherapy in Patients With N2-3 Nasopharyngeal Carcinoma TPF+CCRT vs.CCRT+PF in High Risk Nasopharyngeal Carcinoma Nimotuzumab for Recurrent Nasopharyngeal Carcinoma Adjuvant Treatment of Apatinib in Nasopharyngeal Carcinoma Efficacy of Recombinant Epstein-Barr Virus (EBV) Vaccine in Patients With Nasopharyngeal Cancer Who Had Residual EBV DNA Load After Conventional Therapy Therapeutic Gain by Induction-concurrent Chemoradiotherapy and/or Accelerated Fractionation for Nasopharyngeal Carcinoma Screening Nasopharyngeal Carcinoma With EBV Associated Biomarkers in Zhongshan City SHR-1701 in Patients With Recurrent/Metastatic Nasopharyngeal Carcinoma A Study of Gemcitabine and Cisplatin/Carboplatin Plus Erlotinib in Patients With Nasopharyngeal Cancer Swallowing Pattern of Patients With Nasopharyngeal Cancer Before and After Radiation Therapy: Longitudinal Study and Correction With Saliva Amount Safety and Efficacy Study of Icotinib With Intensity-modulated Radiotherapy in Nasopharyngeal Carcinoma Screening for Nasopharyngeal Carcinoma in High Risk Populations EBV-Specific CTLs Following CD45 Antibody to Patients With Epstein-Barr Virus (EBV) + Nasopharyngeal Carcinoma (NPC) Pilot Study of Somatostatin Receptor Imaging in Nasopharyngeal Cancer A Study of Lymphangiogenesis in Colorectal and Nasopharyngeal Cancer PET/MR in Locally Advanced Nasopharyngeal Carcinoma Bortezomib and Gemcitabine in Treating Patients With Recurrent or Metastatic Nasopharyngeal Cancer Maintenance Treatment of Apatinib in Nasopharyngeal Carcinoma Dendritic Cell Therapy With CD137L-DC-EBV-VAX in Locally Advanced Stage IV or Locally Recurrent/Metastatic Nasopharyngeal Carcinoma Weekly Docetaxel Plus Cisplatin as the First-line Therapy for Nasopharyngeal Cancer Nasopharyngeal Carcinoma Screening in Zhongshan City Nasopharyngeal Carcinoma Post IMRT To Investigate the Molecular Mechanism of Traditional Chinese Medicine Constitution Using Next-generation Sequencing in Nasopharyngeal Carcinoma Avelumab for Recurrent/Metastatic Nasopharyngeal Cancer Parotid-sparing IMRT for Nasopharyngeal Cancer Induction Chemotherapy and Chemoradiotherapy in Nasopharyngeal Cancers A Study of Capecitabine (Xeloda) as First-Line Chemotherapy in Participants With Metastatic Nasopharyngeal Cancer Prospective Nasopharyngeal Carcinoma Screening Using Plasma Epstein-Barr Virus DNA Analysis Assessment of Treatment Response of Nasopharyngeal Cancer Using Simultaneous 18F-FDG-PET and MRI HepaSphere Interventional Therapy Using Digital Subtraction Angiography（DSA） for Nasopharyngeal Carcinoma A Study of Xeloda (Capecitabine) in Combination With XELOX (Oxaliplatin) in Patients With Metastatic Nasopharyngeal Cancer. 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Brief Title

Comparison of Transdermal Fentanyl and Morphine for Oral Mucositis Pain in Nasopharyngeal Cancer Patients

Official Title

A Comparison of Oral Controlled-release Morphine With Transdermal Fentanyl in Nasopharyngeal Cancer Patients With Moderate or Severe Oral Mucositis Pain Induced by Chemoradiotherapy

Brief Summary

      The primary purpose of this study is to explore the significance of analgesic treatment for
      radiation-induced oral mucositis pain in patients with nasopharyngeal carcinoma during
      radiotherapy, and to compare the analgesic effect of morphine controlled-release tablets with
      that of fentanyl transdermal patch. Half of participants will receive morphine
      controlled-release tablets,while the other half will receive fentanyl transdermal patch.

Detailed Description

      Morphine controlled-release tablets and fentanyl transdermal patch each relieve
      radiation-induced oral mucositis pain in patients with nasopharyngeal carcinoma. But they do
      so by different mechanisms and in different effects.

      Morphine is a classic strong analgesic, which has been widely used in patients with advanced
      cancer pain. It has achieved satisfactory results in pain control, sleep improvement and
      quality of life. Oral morphine has been regarded as the standard treatment for moderate and
      severe cancer pain.

      Fentanyl transdermal patch is a system device for transdermal delivery of drugs. It is
      compressed on a film containing fentanyl memory. The film can continuously release fentanyl
      into the blood circulation and maintain stable for more than 72 hours. It is not affected by
      gastrointestinal PH or food, and it has no hepatic frst-pass effect, with a bioavailability
      of up to 92%.

      This study will test the efficacy and safety of morphine controlled-release tablets compared
      to fentanyl transdermal patch in the treatment of pain in patients with radiation-induced
      oral mucositis.

Study Phase

Phase 4

Study Type

Interventional

Primary Outcome

Pain Intensity Measure

Secondary Outcome

 Incidence of Treatment-Related Adverse Events

Condition

Pain

Intervention

Fentanyl

Study Arms / Comparison Groups

 Fentanyl
Description:  Intervention: Drug: Fentanyl Transdermal Patch

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Drug

Estimated Enrollment

300

Start Date

December 2020

Completion Date

December 2021

Primary Completion Date

December 2021

Eligibility Criteria

        Inclusion Criteria:

          -  Patients were pathologically newly diagnosed with nasopharyngeal carcinoma and had no
             previous history of other tumors

          -  According to the treatment strategies of doctors, patients need to receive
             radiotherapy with or without chemotherapy (for example, neoadjuvant chemotherapy,
             concurrent chemotherapy, adjuvant chemotherapy) or targeted therapy

          -  Never use a opioid before treatment

          -  Hematology: WBC≥4.0×109/L, ANC≥1.5×109/L, PLT≥100×109/L,Hb≥90g/L.

          -  Participants with the ability to assess the pain level

          -  Willingness to return to enrolling institution for follow-up

        Exclusion Criteria:

          -  Patients do not conform to the inclusion criteria

          -  Known allergy to fentanyl, morphine, or any known component of the drug formulation

          -  Refuse to use of opioid drugs

          -  Nasopharyngeal patients with mental illness

          -  Current untreated or unresolved oral candidiasis or oral HSV infection

          -  Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment
             of the investigator, would make the patient inappropriate for entry into this study or
             interfere significantly with the proper assessment of safety and toxicity of the
             prescribed regimens

          -  Pregnant or Nursing women

          -  Men or women of childbearing potential who are unwilling to employ adequate
             contraception

          -  Other contraindications or unsuitable conditions for radiotherapy

Gender

All

Ages

18 Years - 70 Years

Accepts Healthy Volunteers

No

Contacts

Jiarong Chen, PhD, 86-0750-3399003, [email protected]

Administrative Informations

NCT ID

NCT04292990

Organization ID

JM0019001

Responsible Party

Sponsor-Investigator

Study Sponsor

Jiarong Chen, MD

Study Sponsor

Jiarong Chen, PhD, Principal Investigator, Affiliated Jiangmen Hospital of Sun Yat-Sen University

Verification Date

July 2020