De-escalation Protocols in Locoregionally Advanced Nasopharyngeal Carcinoma

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Trail Evaluating Carbon Ion Radiotherapy (3 GyE Per Fraction) for Locally Recurrent Nasopharyngeal Carcinoma Intestinal Flora Sequencing for Nasopharyngeal Carcinoma Trial Evaluating Carbon Ion Radiotherapy With Concurrent Chemotherapy for Locally Recurrent Nasopharyngeal Carcinoma Study of Cetuximab in Nasopharyngeal Carcinoma (NPC) With Chemoradiotherapy Molecular Genetics Study of Nasopharyngeal Carcinoma: Characterization of NCP Susceptibility Gene(s) Induction Chemotherapy of TPX in Nomogram-predicted High Risk Locoregionally Advanced Nasopharyngeal Carcinoma Apatinib Combined With PD-1 in the Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma Induction Chemotherapy With GP Versus TPF in the Treatment of Advanced Nasopharyngeal Carcinoma Late-Course Accelerated Hyperfractionated IMRT for Locoregionally Advanced Nasopharyngeal Carcinoma Induction Chemotherapy With Nab-paclitaxel, Cisplatin and Fluorouracil for Locoregionally Advanced Nasopharyngeal Carcinoma Phase III Study of Camrelizumab in Combination With Chemotherapy in Recurrent/Metastatic Nasopharyngeal Carcinoma Docetaxal & Cisplatin vs LDFRT + Docetaxal & Cisplatin in Locally Advanced NPC Aspirin Improve Survival of N2-3 Nasopharyngeal Carcinoma Patients GC Regimen Chemotherapy Plus CIK Cells for Metastatic Nasopharyngeal Carcinoma A Phase III Trial Evaluating Chemotherapy and Immunotherapy for Advanced Nasopharyngeal Carcinoma (NPC) Patients A Phase III Study of Radiotherapy With or Without Adjuvant C/T in Advanced Stage Nasopharyngeal Carcinoma Patients The Value of Concurrent Chemoradiotherapy for Stage II Nasopharyngeal Carcinoma Induction Cisplatin and Capecitabine Followed by Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma Trail Evaluating Carbon Ion Radiotherapy for Locally Recurrent Nasopharyngeal Carcinoma The Value of Single-cycle TPF Induction Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma Effect of Endostar Combined With Intensity-modulated 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Brief Title

De-escalation Protocols in Locoregionally Advanced Nasopharyngeal Carcinoma

Official Title

De-escalation of Chemoradiotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma

Brief Summary

      The purpose of this study is to explore the efficacy and safety of image guided de-escalation
      protocols in patients with locoregionally advanced nasopharyngeal carcinoma (NPC). So the
      investigators studied whether toxicities reducing treatment with omitted concurrent
      chemotherapy after good response to induction chemotherapy would maintain survival outcomes
      while improving tolerability for patients with locoregionally advanced nasopharyngeal
      carcinoma.

Study Type

Interventional

Primary Outcome

DFS

Secondary Outcome

 OS

Condition

Nasopharyngeal Carcinoma

Intervention

Toxicities reduced treatment

Study Arms / Comparison Groups

 Toxicities reduced treatment
Description:  Patients receive docetaxel(75mg/m2 d1) and cisplatin(25 mg/m2 d1-3) every 3 weeks for 3 cycles as induction chemotherapy, followed by omitting concurrent cisplatin chemotherapy when responses to induction chemotherapy are ≥ 50% Partial Response(PR).

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Radiation

Estimated Enrollment

118

Start Date

November 1, 2019

Completion Date

December 31, 2022

Primary Completion Date

December 31, 2022

Eligibility Criteria

        Inclusion Criteria:

          -  Histological diagnosis of nasopharyngeal carcinoma

          -  Stage III or IVA according to UICC/AJCC 8th staging system

          -  Age ≥18

          -  No prior anti-tumor treatment

          -  Karnofsky Performance Score (KPS)≥70

          -  Adequate blood supply

          -  Informed consent obtained

        Exclusion Criteria:

          -  Can not take contrast-MRI imaging

          -  Pregnant

          -  Combined with other malignant tumor (except basal cell carcinoma of skin)

Gender

All

Ages

18 Years - 70 Years

Accepts Healthy Volunteers

No

Contacts

Chaosu Hu, MD, +8613916162859, [email protected]

Location Countries

China

Location Countries

China

Administrative Informations

NCT ID

NCT04158518

Organization ID

2019-NPC001

Responsible Party

Sponsor-Investigator

Study Sponsor

Chaosu Hu

Study Sponsor

Chaosu Hu, MD, Principal Investigator, Fudan University Shanghai Cancer Centre

Verification Date

November 2019