Topotecan and Melphalan for Retinoblastoma

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Brief Title

Topotecan and Melphalan for Retinoblastoma

Official Title

Choice of Topotecan or Melphalan in Retinoblastoma Patients

Brief Summary

      The purpose of this study is to evaluate topotecan and melphalan for retinoblastoma patients.
    

Detailed Description

      To evaluate the effectiveness and complications of topotecan and melphalan for intraocular
      injection in retinoblastoma patients.
    

Study Phase

Phase 3

Study Type

Interventional


Primary Outcome

Eyeball-sparing rate

Secondary Outcome

 Side effects

Condition

Retinoblastoma

Intervention

Topotecan

Study Arms / Comparison Groups

 Topotecan
Description:  Topotecan intraocular injection during chemotherapy

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Drug

Estimated Enrollment

50

Start Date

March 11, 2021

Completion Date

December 30, 2027

Primary Completion Date

December 30, 2024

Eligibility Criteria

        Inclusion Criteria:

          -  diagnosed as retinoblastoma

          -  receiving eyeball-sparing treatment

        Exclusion Criteria:

          -  disease progression during follow-up
      

Gender

All

Ages

N/A - N/A

Accepts Healthy Volunteers

No

Contacts

Huashen Yang, +00862087331539, [email protected]

Location Countries

China

Location Countries

China

Administrative Informations


NCT ID

NCT04799002

Organization ID

202103


Responsible Party

Principal Investigator

Study Sponsor

Sun Yat-sen University


Study Sponsor

Huashen Yang, Principal Investigator, Sun Yat-sen University


Verification Date

March 2021