Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma

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Brief Title

Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma

Official Title

Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma

Brief Summary

      Phase II study of selective intra-arterial infusion of chemotherapy for intraocular
      retinoblastoma
    


Study Phase

Phase 2

Study Type

Interventional


Primary Outcome

Response: Globe salvage rate (Eyes saved/Eyes treated). This will be determined by clinical ocular examination.


Condition

Retinoblastoma

Intervention

Intra-arterial infusion of chemotherapy


Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Procedure

Estimated Enrollment

0

Start Date

September 2010

Completion Date

March 2012

Primary Completion Date

March 2011

Eligibility Criteria

        Inclusion Criteria:

          1. Patients diagnosed with advanced intraocular retinoblastoma (International
             Retinoblastoma Classification group D or E*).

          2. Patients with tumor recurrence or vitreous seeding following completion of systemic
             chemotherapy or previous radiation therapy.

        Exclusion Criteria:

          1. Congenital brain anomaly identified on MRI.

          2. History of systemic coagulopathy.

          3. Evidence of extra ocular retinoblastoma on clinical examination or neuroimaging.
      

Gender

All

Ages

N/A - 18 Years

Accepts Healthy Volunteers

No

Contacts

Jonathan W Kim, , 

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT01151748

Organization ID

PEDSEYE0001

Secondary IDs

SU-07072009-3000

Responsible Party

Sponsor

Study Sponsor

Stanford University


Study Sponsor

Jonathan W Kim, Principal Investigator, Stanford University


Verification Date

May 2012