Brief Title
Photodynamic Therapy With Visudyne for Human Retinoblastoma: A Preliminary Study
Official Title
Photodynamic Therapy With Visudyne for Human Retinoblastoma: A Preliminary Study
Brief Summary
To study the effectiveness and safety profiles of photodynamic therapy (PDT) for the treatment of human retinoblastoma.
Detailed Description
Retinoblastoma is the commonest primary intraocular malignancy in infancy and early childhood. Ophthalmologist are trying to seek other more safe and effective treatment modalities to well control the tumor and preserve the visual function. Photodynamic therapy (PDT) is a potentially therapeutic approach for retinoblastoma which has been underestimated. In this study, we are gonging to investigate the the effectiveness and safety profiles of photodynamic therapy (PDT) for the treatment of human retinoblastoma.
Study Type
Interventional
Primary Outcome
eye enucleation
Condition
Retinoblastoma
Intervention
photodynamic therapy
Study Arms / Comparison Groups
PDT treatment group
Description: All the patients received once PDT with Visudyne® as the initial treatment. Rescue treatment with systemic chemotherapy would be given to patients if tumors were insensitive to PDT treatment, the tumors became larger, or disease relapse.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Drug
Estimated Enrollment
8
Start Date
February 1, 2011
Completion Date
May 30, 2020
Primary Completion Date
May 30, 2018
Eligibility Criteria
Inclusion Criteria: - patients with intraocular retinoblastoma of Group A-D Exclusion Criteria: - (1) patients with intraocular retinoblastoma of group E; (2) patients with extraocular spread; (3); media opacities such as corneal opacity, significant cataract, or vitreous hemorrhage obscuring fundus examination; (4) patients who were allergic to verteporfin or other benzoporphyrin derivatives.
Gender
All
Ages
1 Year - 20 Years
Accepts Healthy Volunteers
No
Contacts
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Location Countries
China
Location Countries
China
Administrative Informations
NCT ID
NCT04429139
Organization ID
2011MEKY0015
Responsible Party
Principal Investigator
Study Sponsor
Sun Yat-sen University
Study Sponsor
, ,
Verification Date
June 2020