Brief Title
Determining Whether Multiple Anesthesia Exposures Affect Cognitive Function for Retinoblastoma Patients
Official Title
Incidence of Neurocognitive Deficits in Patients After Treatment for Retinoblastoma With Multiple Anesthesia Exposures
Brief Summary
The purpose of this study is to see if there is a difference between the development of the
brain (neurodevelopment) in children who have been treated for retinoblastoma with multiple
anesthetic exposures, compared with brain development in children who have never had
anesthesia.
Study Type
Observational
Primary Outcome
Comparing scores in neuropsychological testing results
Condition
Pediatric Retinoblastoma
Intervention
Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V)
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Other
Estimated Enrollment
75
Start Date
May 7, 2018
Completion Date
May 7, 2022
Primary Completion Date
May 7, 2022
Eligibility Criteria
Inclusion Criteria:
- Age ≥ 6 and < 17 years old
- Ability to undergo at least one eye examination without anesthesia prior to current
visit
Exclusion Criteria:
- Diagnosis of any secondary disease associated with developmental delay
- History of second cancer diagnosis
- Legal Blindness
- Past surgery of any type, with the exception of enucleation for retinoblastoma
- Past exposure to anesthesia for purposes other than retinoblastoma examination
- More than one anesthesia encounter before diagnosis at MSK
- Past External Beam Radiation for treatment of retinoblastoma
- Past systemic chemotherapy
- Non-native speaker of English; however, children whose parents speak only Spanish will
be included, because the tests for parents are available in Spanish
Gender
All
Ages
6 Years - 17 Years
Accepts Healthy Volunteers
No
Contacts
Vittoria Arslan Carlon, MD, 212-639-2680, [email protected]
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT03546387
Organization ID
18-126
Responsible Party
Sponsor
Study Sponsor
Memorial Sloan Kettering Cancer Center
Study Sponsor
Vittoria Arslan Carlon, MD, Principal Investigator, Memorial Sloan Kettering Cancer Center
Verification Date
June 2021