Chemotherapy Treatment for Children With Intraocular Germ-Line Retinoblastoma

Learn more about:
Related Clinical Trial
Adjuvant Chemotherapy for High-risk Postenucleation Retinoblastoma A Clinical Study on the Efficacy and Safety of VEC Intravenous Chemotherapy Combined With Conbercept Intravitreal Injection in the Treatment of Retinoblastoma RB Liquid Biopsy Biorepository Topotecan and Melphalan for Retinoblastoma Effect of Anesthetic Drugs on Neurocognitive Function in Children With Retinoblastoma Requiring Multiple Anesthetic Exposure – Preliminary Study Ocular Conservative Treatment for Retinoblastoma : Efficacy of the New Management Strategies and Visual Outcome Nitroglycerin for Intra-arterial Chemotherapy in Pediatric Retinoblastoma. Autonomic Reflexes During Intra-arterial Chemotherapy for Retinoblastoma Therapeutic Recommendations For The Treatment Of Children With A Retinoblastoma Photodynamic Therapy With Visudyne for Human Retinoblastoma: A Preliminary Study Topotecan Episcleral Plaque for Treatment of Retinoblastoma G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor Comprehensive Omics Analysis of Pediatric Solid Tumors and Establishment of a Repository for Related Biological Studies Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor Mobile Health Case Management System for Reducing Pediatric Treatment Abandonment PCI Imaging System in Pediatric Ophthalmology Evaluate Safety and the Oncolitic Adenovirus VCN-01 Activity in Patients With Refractory Retinoblastoma Determining Whether Multiple Anesthesia Exposures Affect Cognitive Function for Retinoblastoma Patients Conservative Treatments of Retinoblastoma Study of Treatment for Patients With Cancer of the Eye -Retinoblastoma Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma Photoscreening for Retinoblastoma RCT of Ballon Technique VS Selective Ophthalmic Artery Infusion For the Retinoblastoma Patients Studying Health Outcomes After Treatment in Patients With Retinoblastoma Chemotherapy Treatment for Children With Intraocular Germ-Line Retinoblastoma Genetic Mutations and Environmental Exposure in Young Patients With Retinoblastoma and in Their Parents and Young Healthy Unrelated Volunteers A Study of the Effectiveness of a Local Injection of Chemotherapy for Retinoblastoma Intra-arterial Chemotherapy for Retinoblastoma Intra-arterial Chemotherapy With Melphalan for the Treatment of Retinoblastoma (RTB) in Advanced Intraocular Stage Determination of the Sensitivity and Specificity of a Smartphone Application to Detect Retinoblastoma Phase I Trial of Periocular Topotecan in Retinoblastoma Episcleral Topotecan for Treatment of Group D Retinoblastoma Can Pretreatment MRI be Used to Predict Intra-arterial Chemotherapy Response in Retinoblastoma? CEV With/Without Periocular Carboplatin Chemotherapy for Extraocular Retinoblastoma Chemotherapy With or Without Radiation Therapy or Observation in Treating Young Patients With Advanced Retinoblastoma Who Have Undergone Surgery to Remove the Eye Combination Chemotherapy, Radiation Therapy, and Bone Marrow Transplantation in Treating Patients With Retinoblastoma Intravitreal Carboplatin for the Treatment of Participants With Recurrent or Refractory Intraocular Retinoblastoma Superselective Intra-arterial Chemotherapy Treatment for Retinoblastoma- 5 Year Results From Turkey Intra-arterial Chemotherapy(Chemosurgery) for Retinoblastoma Adjuvant Chemotherapy for High-risk Retinoblastoma After Enucleation Alternating Systemic Chemotherapy and Intra-Arterial Melphalan (IAM) Chemotherapy in Children With Intra-Ocular Retinoblastoma Chemotherapy in Treating Patients With Retinoblastoma New Strategies to Detect Cancers in Carriers of Mutations in RB1 Pilot Study of Topotecan/Vincristine With Subconjunctival Carboplatin for Patients With Bilateral Retinoblastoma Carboplatin Plus Vincristine in Treating Children With Retinoblastoma Combination Chemotherapy and Cyclosporine Followed by Focal Therapy for Bilateral Retinoblastoma Proton Beam Radiation Therapy for Intraocular and Periocular Retinoblastoma Quality of Life in Children Cured of Retinoblastoma Adjuvant Treatment in Extensive Unilateral Retinoblastoma Primary Enucleated (RB SFCE 2009) Cardio-respiratory Events During Ophthalmic Artery Chemotherapy for Retinoblastoma Under a Deep Anesthesia Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma SPT Screening in Irradiated Hereditary Retinoblastoma Survivors Attention to Retinoblastoma Diagnosed in the Trauma Setting Carboplatin Periocular Injection for Retinoblastoma Morphological Analysis of the Pineal Gland in Pediatric Retinoblastoma Patients Using Magnetic Resonance Imaging Phase II Study Temozolomide for Retinoblastoma Metastatic to the Central Nervous System for Patients From Guatemala Research on the Environment and Children’s Health: Retinoblastoma Intravitreal Injections of Melphalan for Retinoblastoma Efficacy Study of Lucentis in the Treatment of Retinoblastoma Feasibility of Generating Pluripotent Stem Cells From Patients With Familial Retinoblastoma A Study of Intra-Ophthalmic Artery Topotecan Infusion for the Treatment of Retinoblastoma Retinoblastoma Survivor Study: Assessment of General Health and Quality of Life Retinoblastoma Biomarker Study Cancer Biology of Retinoblastoma Intra-arterial Chemotherapy for the Treatment of Intraocular Retinoblastoma Intra-arterial Chemotherapy for Children With Retinoblastoma Molecular Analysis of Retinoblastoma

Brief Title

Chemotherapy Treatment for Children With Intraocular Germ-Line Retinoblastoma

Official Title

Chemotherapy Plus Local Surgical Treatment in Children With Intraocular Germ-Line Retinoblastoma

Brief Summary

      Retinoblastoma is an unusual cancer of early childhood involving tumor is both eyes or, in
      certain circumstances, one eye only. This condition is the result of an abnormal gene which
      makes both retinas (the back of the eye) vulnerable to develop multiple tumors. Growths in
      the eye impair vision temporarily or permanently. These tumors are malignant, which means
      that they can grow within the eye, spread outside of the eye, and be fatal if untreated.

      Standard therapy for bilateral retinoblastoma includes removal of one eye if vision cannot be
      save and radiation treatment of either eye in which vision might be saved. Radiation controls
      tumor growth in the majority of cases. Another standard method is cryotherapy (freezing a
      tumor to kill it). Chemotherapy (medicines used to kill tumor cells) has been used in the
      past for tumor in or outside the eye, but is not standard. Hyperthermia, increasing the
      temperature of a tumor to kill it, is widely performed, and can be done to a retinoblastoma
      tumor by a laser; this method is not standard.

      The problem with removal of an eye is that any hope of vision is lost. The problems with
      radiation include incomplete control of tumor, injury to the eye or surrounding tissue with
      decreased growth, and that (due to the abnormal retinoblastoma gene) children are very
      susceptible to develop other tumors, especially in the tissue which was given radiation.

      The doctors at Children's Memorial Hospital are using a newer form of treatment, including
      laser hyperthermia, chemotherapy and cryotherapy to decrease retinoblastoma tumors. Some may
      be controlled indefinitely, reducing the number of eyes that need radiation or removal.

      OBJECTIVES

        1. To find out how well chemotherapy plus cryotherapy and laser hyperthermia work on
           retinoblastoma tumors.

        2. To find out whether vision can be saved and tumors controlled without radiation or
           removal of the eye.
    


Study Phase

Phase 2

Study Type

Interventional


Primary Outcome

To determine if a multimodal approach can provide durable control of retinoblastoma and specifically:

Secondary Outcome

 To estimate the response rate and duration for primary retinoblastoma tumors to combination therapy with carboplatin and VP-16

Condition

Retinoblastoma

Intervention

Carboplatin


Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Drug

Estimated Enrollment

30

Start Date

April 1996

Completion Date

September 2006


Eligibility Criteria

        Eligibility Criteria:

          -  Initial clinical diagnosis of Retinoblastoma, with Bilateral tumors, OR Unilateral
             tumor with hope for salvage of vision AND Multiple primary tumors, or positive family
             history for retinoblastoma, or age < 12 months

          -  No prior antitumor therapy (except enucleation of one eye)

          -  At least one tumor exceeds 6 mm in diameter

          -  No evidence of dissemination outside the globe

          -  Signed IRB-approved informed consent

          -  Patient/family available for follow-up
      

Gender

All

Ages

N/A - N/A

Accepts Healthy Volunteers

No

Contacts

Stewart Goldman, MD, , 

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT00179920

Organization ID

CNS 0294


Responsible Party

Principal Investigator

Study Sponsor

Ann & Robert H Lurie Children's Hospital of Chicago


Study Sponsor

Stewart Goldman, MD, Principal Investigator, Ann & Robert H Lurie Children's Hospital of Chicago


Verification Date

August 2020