Cancer Biology of Retinoblastoma

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Brief Title

Cancer Biology of Retinoblastoma

Official Title

Cancer Biology of Retinoblastoma

Brief Summary

      Many children with the childhood cancer, Retinoblastoma, have surgery to remove the tumor and
      sometimes the entire eye. The purpose of this study is to collect the extra tissue from
      patients who undergo tumor removal for laboratory experiments that will help us understand
      not only what occurs in retinoblastoma cells but also how cells normally function. Some of
      these studies will include an evaluation of how cells control the way that genes are
      expressed, how cells "know" to become retinal cells, how cells remain retinal cells, how
      cells lose their identity as retinal cells, what changes make retinoblastoma cells different
      from normal retinal cells, and what changes make some retinoblastomas worse than others.
    



Study Type

Observational


Primary Outcome

Change in efficiency of reprogramming in cells with "naturally occurring" retinoblastoma mutations


Condition

Retinoblastoma


Study Arms / Comparison Groups

 retinablastoma tumor tissue
Description:  

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

8

Start Date

July 2012

Completion Date

December 2015

Primary Completion Date

December 2015

Eligibility Criteria

        Inclusion Criteria:

          -  Patient must have retinoblastoma

          -  Patient must be receiving biopsy, partial surgical excision of the tumor, complete
             excision of the tumor, or enucleation of the eye as part of their standard care.

          -  Parental consent

        Exclusion Criteria:

          -  Diagnosis other than Retinoblastoma

          -  No surgical sampling of tumor is planned as part of standard care

          -  Parental preference to not participate.
      

Gender

All

Ages

N/A - 5 Years

Accepts Healthy Volunteers

No

Contacts

Julien Sage, , 

Location Countries

Guatemala

Location Countries

Guatemala

Administrative Informations


NCT ID

NCT01642823

Organization ID

PEDSEYE0002


Responsible Party

Sponsor

Study Sponsor

Stanford University


Study Sponsor

Julien Sage, Principal Investigator, Stanford University


Verification Date

March 2017