Molecular Analysis of Retinoblastoma

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Brief Title

Molecular Analysis of Retinoblastoma

Official Title

Molecular Analysis of Retinoblastoma

Brief Summary

      Retinoblastoma is a childhood tumor of the retina that affects approximately 1 in 18,000
      children. Retinoblastoma is more prevalent in Central America, where most patients present
      with advanced intraocular and extraocular disease. Therefore, we have formed collaboration
      with Central American investigators to provide us with frozen retinoblastoma tumors from
      patients undergoing routine enucleation. The objective of this protocol is to begin to
      identify the mutations and gene expression changes that occur in retinoblastoma cells
      following RB1 gene inactivation in order to more effectively target chemotherapy for treating
      bilateral retinoblastoma.
    

Detailed Description

      This is a biology protocol with no treatment regimen associated. Following routine
      enucleation of the retinoblastoma affected eye, a portion of the tumor will be removed and
      flash frozen and sent to St. Jude for RNA and DNA analysis. Some tissue will undergo
      histopathological analysis and tissue microarrays will be isolated.
    


Study Type

Observational


Primary Outcome

Identify genes exhibiting differential expression within intraocular disease tissue between patients having only intraocular involvement and those having extraocular involvement.


Condition

Retinoblastoma

Intervention

Tissue samples taken from retinoblastoma

Study Arms / Comparison Groups

 Retinoblastoma
Description:  

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Other

Estimated Enrollment

41

Start Date

April 2007

Completion Date

December 2016

Primary Completion Date

December 2016

Eligibility Criteria

        Inclusion Criteria:

          -  Must have clinical diagnosis of retinoblastoma (to be confirmed histologically after
             enucleation)

          -  Legal guardians must willing to sign an informed consent indicating that they are
             aware of this study and its possible benefits. Legal guardians will be given a copy of
             the consent form.

          -  Patient is being seen at this AHOPCA institution:

        Exclusion Criteria:

          -  Ophthalmologist or oncologist is concerned that sampling will interfere with staging.

          -  Diagnosis other than retinoblastoma.

          -  Affiliated hospital is unable to provide pathologic evidence of retinoblastoma.
      

Gender

All

Ages

N/A - N/A

Accepts Healthy Volunteers

No

Contacts

Rachel Brennan, MD, , 

Location Countries

Chile

Location Countries

Chile

Administrative Informations


NCT ID

NCT00718783

Organization ID

MARB

Secondary IDs

1R01EY018599

Responsible Party

Sponsor

Study Sponsor

St. Jude Children's Research Hospital

Collaborators

 National Eye Institute (NEI)

Study Sponsor

Rachel Brennan, MD, Principal Investigator, St. Jude Children's Research Hospital


Verification Date

December 2016