Transcranial Magnetic Stimulation in Progressive Supranuclear Palsy
Cerebellar Transcranial Magnetic Stimulation for Motor Control in Progressive Supranuclear Palsy
The objective of this proposal is to investigate the effect of non-invasive repetitive cerebellar transcranial magnetic stimulation (rTMS) on motor control in progressive supranuclear (PSP). The central hypothesis is that augmenting cerebellar inhibition via cerebellar rTMS will decrease postural instability in patients with PSP by increasing functional connectivity between the cerebellum, thalamus, and primary motor cortex.
Repetitive transcranial magnetic stimulation (rTMS)
Study Arms / Comparison Groups
Active TMS first
Description: After completing their baseline assessment, participants randomized to this arm will initially take part in a 2-week TMS intervention. After the midpoint assessment and subsequent a 1-month washout, these participants will then complete a 2-week sham TMS period prior to their final assessment.
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
January 17, 2020
Primary Completion Date
Inclusion Criteria: - probable or possible PSP by the revised MDS PSP Criteria (Hoglinger 2017) - age 40-85 at time of screening - ability to understand and cooperate with simple instructions in English - ability to read at 6th grade reading level in English - ability to stand unassisted for at least 30 seconds and to be able walk independently with a walker - ability to refrain from new physical and speech therapy programs for the duration of the study - ability to remain on stable doses of any cholinergic, dopaminergic, serotonergic sedative or NMDA receptor antagonists for the duration of the study - females of child-bearing age must perform a urine pregnancy test and be on reliable birth control during the course of the study Exclusion Criteria: - other significant neurological or vestibular disorders - presence of electrically, magnetically or mechanically activated implants or history of injurious metal exposure in eyes, head, or body
40 Years - 85 Years
Accepts Healthy Volunteers
Marian L Dale, MD, MCR, 5034182601, [email protected]
Oregon Health and Science University
National Center of Neuromodulation for Rehabilitation
Marian L Dale, MD, MCR, Principal Investigator, Oregon Health and Science University