Effects of Coenzyme Q10 in PSP and CBD

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Progressive supranuclear palsy
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Brief Title

Effects of Coenzyme Q10 in PSP and CBD

Official Title

Effects of Coenzyme Q10 in PSP and CBD, A Randomized, Placebo-Controlled, Double Blind Cross Over Pilot Study

Brief Summary

      To compare the efficacy, safety and tolerability of Coenzyme Q 10 versus placebo in patients
      with atypical parkinsonian syndromes corticobasal degeneration (CBD) and progressive
      supranuclear palsy (PSP) ).

Study Phase

Phase 2/Phase 3

Study Type

Interventional

Condition

Progressive Supranuclear Palsy

Intervention

CoQ10

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Drug

Start Date

January 2004

Completion Date

September 2005

Eligibility Criteria

        Inclusion Criteria:

          -  Patients fulfilling the diagnostic criteria of PSP and CBD (above) and who were
             diagnosed within the past 5 years

          -  Age > 40

          -  Subjects receiving anticholinergics, amantadine, dopamine agonists,
             carbidopa/levodopa, eldepryl, or comtan must be on a stable dose for at least 30 days
             prior to baseline visit.

          -  Patients agreeable to participate in the study.

        Exclusion Criteria:

          -  Prior or concurrent therapy with anticholinergics, amantadine,a dopamine
             agonist,carbidopa/levodopa or comtan within 30 days of the baseline visit.

          -  Parkinsons disease or any other atypical parkinsonism; Parkinsonism due to drugs.

          -  History of pallidotomy, thalamotomy, deep brain stimulation or fetal tissue
             transplant.

          -  Previous use of coenzyme Q10 within 60 days of the baseline visit.

Gender

All

Ages

40 Years - N/A

Accepts Healthy Volunteers

No

Contacts

Diana Apetauerova, MD, ,

Location Countries

United States

Location Countries

United States

Administrative Informations

NCT ID

NCT00532571

Organization ID

CoQ10 with PSP/CBD

Study Sponsor

Lahey Clinic

Study Sponsor

Diana Apetauerova, MD, Principal Investigator, Lahey Clinic

Verification Date

June 2018