Brief Title
tDCS and Speech Therapy for Motor Speech Disorders Caused by FTLD Syndromes: a Feasibility Study
Official Title
tDCS and Speech Therapy for Motor Speech Disorders Caused by FTLD Syndromes: a Feasibility Study
Brief Summary
The investigators will test the feasibility of using transcranial direct current stimulation
(tDCS) and speech therapy to treat participants with motor speech disorders caused by
Frontotemporal Lobar Degeneration Pathology including nonfluent variant Primary Progressive
Aphasia, Progressive Supranuclear Palsy, Corticobasal Syndrome, or behavioral variant
Frontotemporal Dementia.
The investigators will deliver transcranial direct current stimulation (tDCS) either in a
clinic setting at the University of California San Francisco, or in patients' homes, via a
consumer tDCS device and videoconferencing. Transcranial direct current stimulation (tDCS) is
a neuromodulation technique that can enhance the benefits of speech therapy treatment.
Participants will receive a dose of tDCS stimulation + speech therapy and a dose of sham tDCS
+ speech therapy in a randomized double blind crossover study performed either in the clinic
or at home via videoconferencing. This study can be performed entirely remotely.
Study Type
Interventional
Primary Outcome
Change in speech intelligibility
Secondary Outcome
Feasibility of remote use of device
Condition
Nonfluent Aphasia, Progressive
Intervention
Halo Neuroscience Neurostimulator
Study Arms / Comparison Groups
tDCS +speech therapy followed by sham tDCS + speech therapy
Description:
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Device
Estimated Enrollment
0
Start Date
July 1, 2022
Completion Date
November 30, 2023
Primary Completion Date
November 30, 2023
Eligibility Criteria
Inclusion Criteria:
- Mini Mental Status Exam score > 10
- diagnosis of nfvPPA via Gorno-Tempini 2011 criteria, or a diagnosis of FTLD syndrome
including progressive supranuclear palsy, corticobasal syndrome or behavioral variant
frontotemporal dementia PLUS a motor speech disorder (apraxia of speech and/or
dysarthria)
- able to give consent
- right-handed
- native English speaker
- having a caregiver who is also able to sign and understand the caregiver's consent
form.
Exclusion Criteria: History of:
- stroke
- TBI
- brain cancer
- seizures
- craniotomy, skull surgery or fracture
- metallic implant in head
- pacemaker or cardioverter-defibrillator
- pregnancy.
Gender
All
Ages
18 Years - 95 Years
Accepts Healthy Volunteers
No
Contacts
Maria Luisa Gorno Tempini, MD PhD, ,
Administrative Informations
NCT ID
NCT04883229
Organization ID
18-26098
Responsible Party
Sponsor
Study Sponsor
University of California, San Francisco
Collaborators
Halo Neuroscience
Study Sponsor
Maria Luisa Gorno Tempini, MD PhD, Principal Investigator, University of California, San Francisco
Verification Date
August 2022